Diterpenoids with anti-inflammatory activity from Euphorbia wallichii

被引：17

作者：

Wang, Yali ^{[1
]}

Sun, Dejuan ^{[1
]}

Jiang, Qinghua ^{[3
]}

Xiong, Liangliang ^{[1
]}

Zhang, Na ^{[1
]}

Pan, Yingni ^{[1
]}

Li, Hua ^{[1
,2
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery,Minis, Shenyang 110016, Peoples R China

[2] Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou 350122, Peoples R China

[3] China Med Univ, Shengjing Hosp, Dept Pharm, Shenyang 110004, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 205卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Euphorbia wallichii Hook; f; Euphorbiaceae; ent-Trachylobane diterpenoids; ent-Atisane diterpenoids; ent-Abietane diterpenoids; Anti-inflammatory; NF-KAPPA-B; INFLAMMATION; PLANTS; CONSTITUENTS; ROOTS;

D O I：

10.1016/j.phytochem.2022.113486

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Euphorbia plants are the focus of natural product drug discovery because of their fascinating structural diversity and broad biological activities. Here we reported the discovery of eight undescribed diterpenoids, including two ent-trachylobanes, five ent-atisanes, and one ent-abietane, together with 15 known ones from the whole plant of Euphorbia wallichii. Their chemical structures were elucidated by detailed spectrometry data analysis and X-ray crystallography. Among them, wallichane G represents a rare ent-atisane type pentacyclic diterpenoid featuring a tetrahydrofuran moiety. Furthermore, bioassays indicated that jolkinolide B exhibited potent inhibitory activities on the production of NO, with an IC50 value of 3.84 +/- 0.25 mu M. Meanwhile, the mechanistic study revealed that jolkinolide B could obviously downregulate the expression of iNOS, COX-2, NF kappa B, and phosphorylated I kappa B alpha in a dose-dependent manner and strongly upregulate the expression of Nrf2 and HO-1 protein, thereby suppressing the inflammatory process in macrophage cells induced by LPS.

引用

页数：11

共 39 条

[1] Inflammation Amplifier, a New Paradigm in Cancer Biology [J].