Transient hearing abnormalities precede social deficits in a mouse model of autism

被引:7
作者
Pang, Ruiqi [1 ,2 ]
Yan, Sumei [2 ]
Tu, Yunfeng [3 ]
Qian, Shaowen [2 ]
Yu, Haipeng [1 ,2 ]
Hu, Xianli [2 ]
Wen, Huizhong [2 ]
Yuan, Wei [4 ]
Wang, Xing [3 ]
Zhou, Yi [2 ]
机构
[1] Guangxi Univ, Adv Inst Brain & Intelligence, Sch Med, Nanning 530004, Peoples R China
[2] Army Med Univ, Dept Neurobiol, Chongqing Key Lab Neurobiol, Chongqing 404100, Peoples R China
[3] Chongqing Univ, Bioengn Coll, Dept Biomed Engn, Chongqing 400044, Peoples R China
[4] Chongqing Gen Hosp, Dept Otolaryngol, Chongqing 401147, Peoples R China
关键词
Autism spectrum disorder; Shank3B; Hearing abnormalities; Social deficits; AUDITORY BRAIN-STEM; SHANK3; CHILDREN; HYPERACUSIS; MORPHOLOGY; BEHAVIORS; MUTATIONS; RESPONSES; PROTEINS;
D O I
10.1016/j.bbr.2022.114149
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Hearing abnormalities are important symptoms of autism spectrum disorders (ASDs), a neurological and developmental disorder. However, the characteristics of hearing abnormalities associated with ASD during development have not been fully investigated. We found that in Shank3B knockout mice (a high-confidence mouse model of ASD), transient hearing abnormalities can be found in auditory brainstem response, auditory cortical activity, as well as acoustic startle response. More importantly, all hearing abnormalities at 4 weeks were most prominent and preceded the onset of social deficits at 6 weeks. These hearing abnormalities gradually recovered with age. In addition, analysis of ABR data at 4 weeks using Support Vector Machine (SVM) can faithfully predict the genotype of mice with an accuracy of 85.71%. These findings not only revealed hearing changes in Shank3B knockout autistic-like mice during development, but also suggested that hearing abnor-malities could potentially be used as an early and effective indicator of ASD risk.
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页数:9
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