Hearing abnormalities are important symptoms of autism spectrum disorders (ASDs), a neurological and developmental disorder. However, the characteristics of hearing abnormalities associated with ASD during development have not been fully investigated. We found that in Shank3B knockout mice (a high-confidence mouse model of ASD), transient hearing abnormalities can be found in auditory brainstem response, auditory cortical activity, as well as acoustic startle response. More importantly, all hearing abnormalities at 4 weeks were most prominent and preceded the onset of social deficits at 6 weeks. These hearing abnormalities gradually recovered with age. In addition, analysis of ABR data at 4 weeks using Support Vector Machine (SVM) can faithfully predict the genotype of mice with an accuracy of 85.71%. These findings not only revealed hearing changes in Shank3B knockout autistic-like mice during development, but also suggested that hearing abnor-malities could potentially be used as an early and effective indicator of ASD risk.
机构:
Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Bozdagi, Ozlem
Sakurai, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Sakurai, Takeshi
Papapetrou, Danae
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Papapetrou, Danae
Wang, Xiaobin
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Wang, Xiaobin
Dickstein, Dara L.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Dickstein, Dara L.
Takahashi, Nagahide
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Takahashi, Nagahide
Kajiwara, Yuji
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Kajiwara, Yuji
Yang, Mu
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Yang, Mu
Katz, Adam M.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Katz, Adam M.
Scattoni, Maria Luisa
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA
Ist Super Sanita, I-00161 Rome, ItalyMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Scattoni, Maria Luisa
Harris, Mark J.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Harris, Mark J.
Saxena, Roheeni
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Saxena, Roheeni
Silverman, Jill L.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Silverman, Jill L.
Crawley, Jacqueline N.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Crawley, Jacqueline N.
Zhou, Qiang
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
Genentech Inc, San Francisco, CA 94080 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Zhou, Qiang
Hof, Patrick R.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Hof, Patrick R.
Buxbaum, Joseph D.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Dickinson, Abigail
Daniel, Manjari
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Daniel, Manjari
Marin, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Marin, Andrew
Gaonkar, Bilwaj
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Neurosurg, Ronald Reagan UCLA Med Ctr, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Gaonkar, Bilwaj
Dapretto, Mirella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Dapretto, Mirella
McDonald, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
McDonald, M.
Jeste, Shafali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
机构:
Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Bozdagi, Ozlem
Sakurai, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Sakurai, Takeshi
Papapetrou, Danae
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Papapetrou, Danae
Wang, Xiaobin
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Wang, Xiaobin
Dickstein, Dara L.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Dickstein, Dara L.
Takahashi, Nagahide
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Takahashi, Nagahide
Kajiwara, Yuji
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Kajiwara, Yuji
Yang, Mu
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Yang, Mu
Katz, Adam M.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Katz, Adam M.
Scattoni, Maria Luisa
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA
Ist Super Sanita, I-00161 Rome, ItalyMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Scattoni, Maria Luisa
Harris, Mark J.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Harris, Mark J.
Saxena, Roheeni
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Saxena, Roheeni
Silverman, Jill L.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Silverman, Jill L.
Crawley, Jacqueline N.
论文数: 0引用数: 0
h-index: 0
机构:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Crawley, Jacqueline N.
Zhou, Qiang
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
Genentech Inc, San Francisco, CA 94080 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Zhou, Qiang
Hof, Patrick R.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Hof, Patrick R.
Buxbaum, Joseph D.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USAMt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Dickinson, Abigail
Daniel, Manjari
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Daniel, Manjari
Marin, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Marin, Andrew
Gaonkar, Bilwaj
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Neurosurg, Ronald Reagan UCLA Med Ctr, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Gaonkar, Bilwaj
Dapretto, Mirella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
Dapretto, Mirella
McDonald, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
McDonald, M.
Jeste, Shafali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA