The effects of high and low dose extracorporeal shockwave therapy on immune activation and immunosuppressive markers in elderly patients with osteoarthritis: a study protocol for a randomized controlled trial

被引：2
作者：
Sheng, Yilan [1 ,2 ]
Yuan, Haiyin [1 ]
Chen, Lihua [1 ]
Yu, Bo [1 ,2 ]
机构：
[1] Shanghai Fifth Rehabil Hosp, Dept Rehabil, 279 Leda Rd, Shanghai 201600, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Rehabil, 100 Haining Rd, Shanghai 200080, Peoples R China
来源：
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2023年 / 12卷 / 06期
关键词：
Shockwave therapy; elderly patients; osteoarthritis; immunology; KNEE OSTEOARTHRITIS; PROGRESSION; PAIN;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective: This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis. Methods: 120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm(2)) or low dose (0.10 mJ/mm(2)) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up. Results: High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly. Conclusion: This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.
引用
收藏
页码：164 / 172
页数：9
相关论文
共 24 条
  • [1] OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis
    Bannuru, R. R.
    Osani, M. C.
    Vaysbrot, E. E.
    Arden, N. K.
    Bennell, K.
    Bierma-Zeinstra, S. M. A.
    Kraus, V. B.
    Lohmander, L. S.
    Abbott, J. H.
    Bhandari, M.
    Blanco, F. J.
    Espinosa, R.
    Haugen, I. K.
    Lin, J.
    Mandl, L. A.
    Moilanen, E.
    Nakamura, N.
    Snyder-Mackler, L.
    Trojian, T.
    Underwood, M.
    McAlindon, T. E.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2019, 27 (11) : 1578 - 1589
  • [2] HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways
    Bao, Chuncha
    Zhu, Siyi
    Song, Kangping
    He, Chengqi
    [J]. CELL COMMUNICATION AND SIGNALING, 2022, 20 (01)
  • [3] Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study
    Chen, H. -C.
    Shah, S.
    Stabler, T. V.
    Li, Y-J.
    Kraus, V. B.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2008, 16 (09) : 1054 - 1059
  • [4] Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-β1 and 1GF-1 expression
    Chen, YJ
    Wang, CJ
    Yang, KD
    Kuo, YR
    Huang, HC
    Huang, YT
    Sun, YC
    Wang, FS
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2004, 22 (04) : 854 - 861
  • [5] Measurement Properties of Visual Analogue Scale, Numeric Rating Scale, and Pain Severity Subscale of the Brief Pain Inventory in Patients With Low Back Pain: A Systematic Review
    Chiarotto, Alessandro
    Maxwell, Lara J.
    Ostelo, Raymond W.
    Boers, Maarten
    Tugwell, Peter
    Terwee, Caroline B.
    [J]. JOURNAL OF PAIN, 2019, 20 (03) : 245 - 263
  • [6] Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees
    Collins, Kelsey H.
    Hart, David A.
    Reimer, Raylene A.
    Seerattan, Ruth A.
    Herzog, Walter
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2016, 34 (06) : 1010 - 1018
  • [7] Measures of Knee Function International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS)
    Collins, Natalie J.
    Misra, Devyani
    Felson, David T.
    Crossley, Kay M.
    Roos, Ewa M.
    [J]. ARTHRITIS CARE & RESEARCH, 2011, 63 : S208 - S228
  • [8] Association of Pain in Knee Osteoarthritis With Distinct Patterns of Synovitis
    de Lange-Brokaar, B. J. E.
    Ioan-Facsinay, A.
    Yusuf, E.
    Visser, A. W.
    Kroon, H. M.
    van Osch, G. J. V. M.
    Zuurmond, A. -M.
    Stojanovic-Susulic, V.
    Bloem, J. L.
    Nelissen, R. G. H. H.
    Huizinga, T. W.
    Kloppenburg, M.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2015, 67 (03) : 733 - 740
  • [9] Extracorporeal Shock Wave Therapy Reverses Ischemia-Related Left Ventricular Dysfunction and Remodeling: Molecular-Cellular and Functional Assessment
    Fu, Morgan
    Sun, Cheuk-Kwan
    Lin, Yu-Chun
    Wang, Ching-Jen
    Wu, Chiung-Jen
    Ko, Sheung-Fat
    Chua, Sarah
    Sheu, Jiunn-Jye
    Chiang, Chiang-Hua
    Shao, Pei-Lin
    Leu, Steve
    Yip, Hon-Kan
    [J]. PLOS ONE, 2011, 6 (09):
  • [10] 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis
    Grayson, Peter C.
    Ponte, Cristina
    Suppiah, Ravi
    Robson, Joanna C.
    Craven, Anthea
    Judge, Andrew
    Khalid, Sara
    Hutchings, Andrew
    Luqmani, Raashid A.
    Watts, Richard A.
    Merkel, Peter A.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (03) : 309 - 314
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