Bridging the age gap: a review of molecularly informed treatments for glioma in adolescents and young adults

被引：8

作者：

Weiser, Annette ^{[1
,2
]}

Bergman, Astrid Sanchez ^{[1
]}

Machaalani, Charbel ^{[1
]}

Bennett, Julie ^{[3
,4
]}

Roth, Patrick ^{[5
,6
]}

Reimann, Regina R. ^{[7
]}

Nazarian, Javad ^{[8
,9
]}

Stucklin, Ana S. Guerreiro ^{[1
,2
]}

机构：

[1] Univ Childrens Hosp Zurich, Childrens Res Ctr, Translat Brain Tumor Res Grp, Zurich, Switzerland

[2] Univ Childrens Hosp Zurich, Div Oncol, Zurich, Switzerland

[3] Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada

[4] Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada

[5] Univ Hosp Zurich, Dept Neurol, Zurich, Switzerland

[6] Univ Zurich, Zurich, Switzerland

[7] Univ Hosp Zurich, Inst Neuropathol, Zurich, Switzerland

[8] Univ Childrens Hosp Zurich, Diffuse Midline Glioma DMG, Childrens Res Ctr, Dept Pediat,Diffuse Intrins Pontine Glioma DIPG Ct, Zurich, Switzerland

[9] Childrens Natl Hosp, Res Ctr Genet Med, Washington, DC USA

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

基金：

瑞士国家科学基金会;

关键词：

gliomas; AYA (adolescents and young adults); WHO CNS5; targeted therapy; BRAF; histone mutations; PI3K-AKT pathway; IDH mutation; LOW-GRADE GLIOMA; NEWLY-DIAGNOSED GLIOBLASTOMA; GIANT-CELL ASTROCYTOMAS; CENTRAL-NERVOUS-SYSTEM; PHASE-II TRIAL; RECURRENT GLIOBLASTOMA; T-CELLS; OPTIC PATHWAY; BRAF V600E; EGFR;

D O I：

10.3389/fonc.2023.1254645

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gliomas are the most common primary central nervous system (CNS) tumors and a major cause of cancer-related mortality in children (age <15 years), adolescents and young adults (AYA, ages 15-39 years), and adults (age >39 years). Molecular pathology has helped enhance the characterization of these tumors, revealing a heterogeneous and ever more complex group of malignancies. Recent molecular analyses have led to an increased appreciation of common genomic alterations prevalent across all ages. The 2021 World Health Organization (WHO) CNS tumor classification, 5th edition (WHO CNS5) brings forward a nomenclature distinguishing "pediatric-type" and "adult-type" gliomas. The spectrum of gliomas in AYA comprises both "pediatric-like" and "adult-like" tumor entities but remains ill-defined. With fragmentation of clinical management between pediatric and adult centers, AYAs face challenges related to gaps in medical care, lower rates of enrollment in clinical trials and additional psychosocial and economic challenges. This calls for a rethinking of diagnostic and therapeutic approaches, to improve access to appropriate testing and potentially beneficial treatments to patients of all ages.

引用

页数：11

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