Ibrutinib and tracheal mucormycosis: A case report and systematic review of literature

被引：3

作者：

Damaraju, Vikram ^{[1
]}

Agarwal, Ritesh ^{[1
]}

Sehgal, Inderpaul Singh ^{[1
]}

Khadwal, Alka ^{[2
]}

Bal, Amanjit ^{[3
]}

Rudramurthy, Shivaprakash Mandya ^{[4
]}

Muthu, Valliappan ^{[1
,5
]}

机构：

[1] Postgrad Inst Med Educ & Res PGIMER, Dept Pulm Med, Chandigarh, India

[2] Postgrad Inst Med Educ & Res PGIMER, Dept Clin Hematol & Oncol, Chandigarh, India

[3] Postgrad Inst Med Educ & Res PGIMER, Dept Histopathol, Chandigarh, India

[4] Postgrad Inst Med Educ & Res PGIMER, Dept Med Microbiol, Chandigarh, India

[5] Postgrad Inst Med Educ & Res, Dept Pulm Med, Sect 12, Chandigarh 160012, India

来源：

JOURNAL DE MYCOLOGIE MEDICALE | 2023年 / 33卷 / 03期

关键词：

Mucormycosis; Ibrutinib; Zygomycosis; Aspergillosis; Leukemia; CHRONIC LYMPHOCYTIC-LEUKEMIA; KINASE INHIBITOR; FUNGAL-INFECTION; PATIENT;

D O I：

10.1016/j.mycmed.2023.101414

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, has been approved for various hematological malignan-cies. Invasive aspergillosis is a known complication of ibrutinib, but mucormycosis is rare. We describe the case of a 70-year-old man with mantle cell lymphoma infiltrating the trachea, managed with a tracheobron-chial stent and ibrutinib. He had improved one month after treatment, and we removed the airway stent. Four months later, he developed tracheal nodules confirmed to be tracheal mucormycosis and responded to liposomal amphotericin B (3.5 g) followed by posaconazole. After transient improvement, the tracheal lesions recurred, the biopsy showed lymphoma (with no evidence of mucormycosis), and he died. A systematic review of the literature identified 20 additional cases of ibrutinib-associated mucormycosis. Most of the 21 patients included were men (95%), and ibrutinib was the only risk factor in 15.7%. The reported mortality was 31.6% (6/19), attributable to mucormycosis in half the cases.& COPY; 2023 SFMM. Published by Elsevier Masson SAS. All rights reserved.

引用

页数：4

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