Local delivery systems of drugs/biologicals for the management of burn wounds

Severe burn injuries are one of the major challenging health issues and pertain to significant morbidity and mortality due to their extensive traumatic and physiological damage to the organs. For decades, crucial steps and procedures have been considered to comprehend burn management. Early debridement and graft application are common practices that have improved the conditions and outcomes of burn patients physically and cosmetically. However, many drawbacks are still arising while managing burn treatment. Delayed healing, scarring, infection, and pain are among the reasons. Moreover, it is necessary to overstep to bring up new techniques and medications for improved healing quality. In this present article, we review and discuss the latest treatment of burn wound management and treatment. This review aims to provide a comprehensive discussion of the use of antibiotics and metallic ions for local delivery at wound sites and also provides a thorough briefing of the mechanism of action of these therapeutic agents. Furthermore, this article also provides an overall scenario of burn wound management, different regulations, and the advancement of nanotherapeutics for burn wound management and novel strategies developed in the past decades. Overall, this review article primarily targets to provide the scientific community with some settler ideas and research advancements, that improve and uplift burn wound care with a focus on infections, scarring, drug deliveries, nanomaterial, growth factors, bioactive proteins, and tissue engineering.