We study the Kahler-Einstein manifolds which admits a holomorphic isometry into either the generalized Burns-Simanca manifold (C-n, gS) or the Eguchi-Hanson manifold ((C) over tilde (2), gEH). Moreover, we prove that ((C) over tilde (n), gS) and ((C) over tilde (2), gEH) are not relatives to any homogeneous bounded domain.