Facile biosynthesis of copper oxide nanoparticles using Mangifera indica leaf extract: Characterization and bioactivities

被引:5
|
作者
Cong, Che Quang [1 ,2 ,3 ]
Tai, Le Tan [1 ,2 ,3 ]
Dat, Nguyen Minh [1 ,2 ,3 ]
Huong, Le Minh [1 ,2 ,3 ]
Hai, Nguyen Duy [1 ,2 ,3 ]
Nam, Nguyen Thanh Hoai [1 ,2 ,3 ]
An, Hoang [1 ,2 ,3 ]
Hung, Nguyen Quoc [1 ,2 ,3 ]
Tri, Huynh Minh [1 ,2 ,3 ]
Phong, Mai Thanh [1 ,2 ,3 ]
Hieu, Nguyen Huu [1 ,2 ,3 ]
机构
[1] Ho Chi Minh City Univ Technol HCMUT, Key Lab Chem Engn & Petr Proc, Key CEPP Lab, VNU HCM, 268 Ly Thuong Kiet St,Dist 10, Ho Chi Minh City, Vietnam
[2] Ho Chi Minh City Univ Technol HCMUT, Fac Chem Engn, 268 Ly Thuong Kiet St,Dist 10, Ho Chi Minh City, Vietnam
[3] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Ho Chi Minh City, Vietnam
关键词
Copper oxide nanoparticles; Antibacterial; Anticancer; Cytotoxicity;
D O I
10.1016/j.matlet.2023.133996
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
In this study, copper oxide nanoparticles (CuONPs) were facilely synthesized via a bio-pathway with the Man-gifera indica leaf extract. The characterization results showed the development of monoclinic CuO as relatively stable nanospheres (15 - 40 nm) and also confirmed the great stability of the CuONPs. Bioactivities of CuONPs were assessed against bacteria strains and cytotoxicity. Accordingly, the CuO-2 sample well-restrained the microbe with over 60 % of inhibition at 50 mu g/mL as well as exhibited excellent cytotoxicity, especially low IC50 value towards the cancerous HepG2 (1.98 mu g/mL). The material also exhibited a negligible inhibitory against normal HEK293 cell lines, which affirms the great biocompatibility in the anticancer activity. Conclusively, green-synthesized CuONPs show good bioactivities and are highly promising for medical applications.
引用
收藏
页数:4
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