Convenient "on-water" one-pot, synthesis of flavonols catalyzed by LiOH.H2O- and H2O2-mediated oxidation

被引：3

作者：

Kumar, Sumit ^{[1
]}

Ambatwar, Ramesh ^{[1
]}

Gupta, Vaibhav ^{[1
]}

Khatik, Gopal L. ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res Raebareli, Dept Med Chem, New Transit Campus, Bijnor Sisendi Rd,Near CRPF Base Camp, Lucknow 226301, Uttar Pradesh, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2023年 / 49卷 / 03期

关键词：

On-water; Catalysis; Efficient synthesis; One-pot synthesis; Flavonols; CHEMISTRY; CONDENSATION; EXPLORATION; DERIVATIVES; EXTRACTION; EFFICIENT;

D O I：

10.1007/s11164-022-04932-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water is an eco-friendly and economical solvent in organic synthesis. The ultrasound-assisted chemical reactions have proven to produce a better yield than the existing traditional approaches. Flavonol scaffold is widely distributed in nature. Therefore, it becomes very important to explore and develop a newer method for their synthesis. In the present work, we have described the one-pot efficient synthesis of flavonol and its derivatives using the LiOH.H2O and H2O2 system. Herein we utilized an eco-friendly chemistry approach using ultrasound and water as a medium to afford flavonols in good yields. LiOH.H2O was found to be a mild base to generate the chalcone intermediate whereas H2O2 acted as an oxidizing agent to produce a flavonol as revealed by a mechanistic study using mass spectrometry and NMR spectroscopy. This one-pot synthesis of flavonols is an effective alternative to the existing methods with the advantages of utilizing mild base and oxidant, ease in isolation, economical, eco-friendly, and good yields.

引用

页码：901 / 915

页数：15

共 47 条

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