Kaempferol attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by a hypoglycaemic effect and concomitant activation of the Nrf-2/Ho-1/antioxidants axis

被引：51

作者：

Alshehri, Ali S. ^{[1
]}

机构：

[1] King Khalid Univ, Coll Sci, Biol Dept, Abha, Saudi Arabia

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2023年 / 129卷 / 04期

关键词：

Kaempferol; diabetes mellitus; kidney; nephropathy; oxidative stress; Nrf-2;

D O I：

10.1080/13813455.2021.1890129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study examined the protective effect of Kaempferol against streptozotocin-induced diabetic nephropathy (DN) in rats and studies the underlying mechanisms. Rats were divided into 4 groups as control, control + Kaempferol, STZ, and STZ + Kaempferol. All treatments were conducted for 8 weeks daily after the induction of diabetes. Kaempferol prevented STZ-induced weight and food loss and attenuated renal damage and the alterations in all biochemical related parameters. Concomitantly, Kaempferol reduced renal levels of TNF-alpha and IL-6, cleaved caspase-3, p38, and Bax, suppressing JNK phosphorylation and NF-kappa B p65 transactivation, and upregulation of Bcl-2. In both control and STZ-diabetic rats, Kaempferol reduced fasting glucose levels, increased fasting insulin levels and HOMA-beta, reduced the levels of ROS and MDA, stimulated SOD and GSH levels, and increased the expression of Nrf2 and HO-1. In conclusion, Kaempferol prevents STZ-induced diabetic nephropathy, mainly, by antioxidant potential, mediated by the upregulation of the Nrf-2/HO-1 axis.

引用

页码：984 / 997

页数：14

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