Near infrared-responsive quinacrine-gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR plus breast cancer stem cells

被引：1
作者：
Dash, Somya Ranjan [1 ]
Das, Chinmay [1 ]
Das, Biswajit [1 ]
Jena, Atala Bihari [2 ]
Paul, Subarno [1 ]
Sinha, Saptarshi [1 ]
Tripathy, Jasaswini [3 ]
Kundu, Chanakya Nath [1 ]
机构：
[1] Deemed Univ, Kalinga Inst Ind Technol KIIT, Sch Biotechnol, Canc Biol Div, Bhubaneswar 751024, Odisha, India
[2] Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci NCCS, Pune, India
[3] Deemed Univ, Kalinga Inst Ind Technol KIIT, Sch Appl Sci Chem, Bhubaneswar 751024, Odisha, India
来源：
NANOMEDICINE | 2024年 / 19卷 / 07期
关键词：
histone acetylation; HSP-70; MCF-7-CSCs; near-infrared; P300; quinacrine-gold hybrid nanoparticle; T47D-CSCs; TGF-beta; MEDIATED APOPTOSIS; HISTONE; MODULATION; CHROMATIN; PROTEIN; PATHWAY; BETA; BER;
D O I：
10.2217/nnm-2023-0269
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: This study aimed to determine if quinacrine-gold hybrid nanoparticles (QAuNPs) + near-infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in Estrogen receptor/Progesterone receptor (ER/PR+) breast cancer stem cells (CSCs). Materials & methods: Various cells and mouse-based systems were used as models. Results: QAuNP + NIR treatment reduced the nuclear translocation of HSP-70, affected the histone acetyltransferase activity of P300 and specifically decreased H3K14 acetylation in ER/PR+ breast CSCs. Finally, HSP-70 knockdown showed a reduction in P300 histone acetyltransferase activity, decreased H3K14 acetylation and inhibited activation of the TGF-beta gene. Conclusion: This study revealed that QAuNP + NIR irradiation inhibits oncogenic activation of the TGF-beta gene by decreasing H3K14 acetylation mediated through the HSP-70/P300 nuclear complex in ER/PR+ breast CSCs.
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收藏
页码：581 / 596
页数：16
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