Advances in Magnetic Carbon Dots: A Theranostics Platform for Fluorescence/Magnetic Resonance Bimodal Imaging and Therapy for Tumors

被引：15
作者：
Zhong, Yamei [1 ]
Chen, Lin [1 ,2 ]
Yu, Shiping [3 ]
Yang, Yongzhen [1 ,2 ]
Liu, Xuguang [4 ]
机构：
[1] Taiyuan Univ Technol, Key Lab Interface Sci & Engn Adv Mat, Minist Educ, Taiyuan 030024, Peoples R China
[2] Shanxi Zheda Inst Adv Mat & Chem Engn, Taiyuan 030032, Peoples R China
[3] Shanxi Med Univ, Chinese Acad Med Sci, Shanxi Prov Canc Hosp, Shanxi Hosp,Canc Hosp, Taiyuan 030013, Peoples R China
[4] Taiyuan Univ Technol, Coll Mat Sci & Engn, Taiyuan 030024, Peoples R China
来源：
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2023年 / 9卷 / 12期
基金：
中国国家自然科学基金;
关键词：
magnetic carbon dots; fluorescence; magneticresonance; bimodal imaging; theranostics; QUANTUM-DOTS; FACILE PREPARATION; RESEARCH PROGRESS; CANCER-DIAGNOSIS; RARE-EARTH; NANOPARTICLES; NANOPROBE; EMISSION;
D O I：
10.1021/acsbiomaterials.3c00988
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Theranostics technology that combines tumor diagnosis or monitoring with therapy is an important direction for the future development of tumor treatment. It takes advantage of efficiently observing tumor tissues, monitoring tumor treatment in real time, and significantly improving the cure efficiency. Magnetic carbon dots (CDs) are of wide interest as molecular imaging probes, drug carriers, photosensitizers, and radiosensitizers in the integration of tumor fluorescence/magnetic resonance bimodal diagnosis and treatment because of their small size, good optical stability, magnetic relaxation rate, and biocompatibility. This review first analyzes and compares the synthesis methods and physicochemical properties of magnetic CDs in recent years and then concludes their mechanism in tumor fluorescence/magnetic resonance bimodal imaging and therapy in details. Subsequently, the research progress of their application in tumor theranostics are summarized. Finally, the problems and challenges of magnetic CDs for development at this stage are prospected. This review provides new ideas for their controlled synthesis and application in efficient and precise therapy for tumors.
引用
收藏
页码：6548 / 6566
页数：19
相关论文
共 101 条
[71]  
[王林鹏 Wang Linpeng], 2015, [材料工程, Journal of Materials Engineering], V43, P101
[72]   Regulating photochemical properties of carbon dots for theranostic applications [J].
Wang, Qin ;
Pang, E. ;
Tan, Qiuxia ;
Zhao, Shaojing ;
Yi, Jianing ;
Zeng, Jie ;
Lan, Minhuan .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2023, 15 (03)
[73]   Enhanced-fluorescent imaging and targeted therapy of liver cancer using highly luminescent carbon dots-conjugated foliate [J].
Wang, Shicai ;
Chen, Lin ;
Wang, Junli ;
Du, Jinglei ;
Li, Qiang ;
Gao, Yuduan ;
Yu, Shiping ;
Yang, Yongzhen .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 116
[74]   Multifunctional red carbon dots: a theranostic platform for magnetic resonance imaging and fluorescence imaging-guided chemodynamic therapy [J].
Wang, Wentao ;
Zhang, Qicheng ;
Zhang, Ming ;
Liu, Yihan ;
Shen, Jian ;
Zhou, Ninglin ;
Lu, Xiaoyuan ;
Zhao, Changhong .
ANALYST, 2020, 145 (10) :3592-3597
[75]  
Wang X., 2010, China. Prac. Med, V5, P247
[76]   Mn(II)-coordinated Fluorescent Carbon Dots: Preparation and Discrimination of Organic Solvents [J].
Wang, Yuru ;
Wang, Tianren ;
Chen, Xi ;
Xu, Yang ;
Li, Huanrong .
OPTICAL MATERIALS, 2018, 78 :118-125
[77]   Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1MRI Contrast Agents in Renal Failure Rats [J].
Weng, Qinjie ;
Hu, Xi ;
Zheng, Jiahuan ;
Xia, Fan ;
Wang, Nan ;
Liao, Hongwei ;
Liu, Ying ;
Kim, Dokyoon ;
Liu, Jianan ;
Li, Fangyuan ;
He, Qiaojun ;
Yang, Bo ;
Chen, Chunying ;
Hyeon, Taeghwan ;
Ling, Daishun .
ACS NANO, 2019, 13 (06) :6801-6812
[78]   Ln(III) chelates-functionalized carbon quantum dots: Synthesis, optical studies and multimodal bioimaging applications [J].
Wu, Fengshou ;
Yue, Liangliang ;
Yang, Lixia ;
Wang, Kai ;
Liu, Genyan ;
Luo, Xiaogang ;
Zhu, Xunjin .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 175 :272-280
[79]   Evolution and Synthesis of Carbon Dots: From Carbon Dots to Carbonized Polymer Dots [J].
Xia, Chunlei ;
Zhu, Shoujun ;
Feng, Tanglue ;
Yang, Mingxi ;
Yang, Bai .
ADVANCED SCIENCE, 2019, 6 (23)
[80]   Tannin-Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging [J].
Xu, Weibing ;
Zhang, Jia ;
Yang, Zhijie ;
Zhao, Minzhi ;
Long, Haitao ;
Wu, Qingfeng ;
Nian, Fang .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2022, 33 (02)
234567891011