miRNAs and related genetic biomarkers according to the WHO glioma classification: From diagnosis to future therapeutic targets

被引：11
作者：
Nikolova, Emiliya [1 ,2 ,5 ]
Laleva, Lili [3 ]
Milev, Milko [3 ]
Spiriev, Toma [3 ]
Stoyanov, Stoycho [3 ]
Ferdinandov, Dilyan [4 ]
Mitev, Vanyo [1 ]
Todorova, Albena [1 ,2 ]
机构：
[1] Med Univ Sofia, Dept Med Chem & Biochem, Sofia 1431, Bulgaria
[2] Independent Med Diagnost Lab Genome Ctr Bulgaria, Sofia, Bulgaria
[3] Acibadem City Clin Tokuda Univ Hosp, Dept Neurosurg, Sofia 1407, Bulgaria
[4] Med Univ Sofia, Dept Neurosurg, Sofia 1431, Bulgaria
[5] 2 Zdrave Str, Sofia 1431, Bulgaria
来源：
NON-CODING RNA RESEARCH | 2024年 / 9卷 / 01期
关键词：
miRNA; Genetic aberration; Brain tumor classification; Glioma; Biomarker; EPITHELIAL-MESENCHYMAL TRANSITION; TEMOZOLOMIDE-INDUCED APOPTOSIS; TERT PROMOTER MUTATIONS; TUMOR-SUPPRESSOR; BRAIN-TUMORS; HIGH-GRADE; HEPATOCELLULAR-CARCINOMA; BLADDER-CANCER; GLIOBLASTOMA; GROWTH;
D O I：
10.1016/j.ncrna.2023.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the 2021 WHO classification of Tumors of the Central Nervous System, additional molecular characteristics have been included, defining the following adult-type diffuse glioma entities: Astrocytoma IDH-mutant, Oligodendroglioma IDH-mutant and 1p/19q-codeleted, and Glioblastoma IDH-wildtype. Despite advances in genetic analysis, precision oncology, and targeted therapy, malignant adult-type diffuse gliomas remain "hard-to-treat tumors", indicating an urgent need for better diagnostic and therapeutic strategies. In the last decades, miRNA analysis has been a hotspot for researching and developing diagnostic, prognostic, and predictive biomarkers for various disorders, including brain cancer. Scientific interest has recently been directed towards therapeutic applications of miRNAs, with encouraging results. Databases such as NCBI, PubMed, and Medline were searched for a selection of articles reporting the relationship between deregulated miRNAs and genetic aberrations used in the latest WHO CNS classification. The current review discussed the recommended molecular biomarkers and genetic aberrations based on the 2021 WHO classification in adult-type diffuse gliomas, along with associated deregulated miRNAs. Additionally, the study highlights miRNA-based treatment advancements in adults with gliomas.
引用
收藏
页码：141 / 152
页数：12
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