miRNAs and related genetic biomarkers according to the WHO glioma classification: From diagnosis to future therapeutic targets

被引：11
作者：
Nikolova, Emiliya [1 ,2 ,5 ]
Laleva, Lili [3 ]
Milev, Milko [3 ]
Spiriev, Toma [3 ]
Stoyanov, Stoycho [3 ]
Ferdinandov, Dilyan [4 ]
Mitev, Vanyo [1 ]
Todorova, Albena [1 ,2 ]
机构：
[1] Med Univ Sofia, Dept Med Chem & Biochem, Sofia 1431, Bulgaria
[2] Independent Med Diagnost Lab Genome Ctr Bulgaria, Sofia, Bulgaria
[3] Acibadem City Clin Tokuda Univ Hosp, Dept Neurosurg, Sofia 1407, Bulgaria
[4] Med Univ Sofia, Dept Neurosurg, Sofia 1431, Bulgaria
[5] 2 Zdrave Str, Sofia 1431, Bulgaria
来源：
NON-CODING RNA RESEARCH | 2024年 / 9卷 / 01期
关键词：
miRNA; Genetic aberration; Brain tumor classification; Glioma; Biomarker; EPITHELIAL-MESENCHYMAL TRANSITION; TEMOZOLOMIDE-INDUCED APOPTOSIS; TERT PROMOTER MUTATIONS; TUMOR-SUPPRESSOR; BRAIN-TUMORS; HIGH-GRADE; HEPATOCELLULAR-CARCINOMA; BLADDER-CANCER; GLIOBLASTOMA; GROWTH;
D O I：
10.1016/j.ncrna.2023.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the 2021 WHO classification of Tumors of the Central Nervous System, additional molecular characteristics have been included, defining the following adult-type diffuse glioma entities: Astrocytoma IDH-mutant, Oligodendroglioma IDH-mutant and 1p/19q-codeleted, and Glioblastoma IDH-wildtype. Despite advances in genetic analysis, precision oncology, and targeted therapy, malignant adult-type diffuse gliomas remain "hard-to-treat tumors", indicating an urgent need for better diagnostic and therapeutic strategies. In the last decades, miRNA analysis has been a hotspot for researching and developing diagnostic, prognostic, and predictive biomarkers for various disorders, including brain cancer. Scientific interest has recently been directed towards therapeutic applications of miRNAs, with encouraging results. Databases such as NCBI, PubMed, and Medline were searched for a selection of articles reporting the relationship between deregulated miRNAs and genetic aberrations used in the latest WHO CNS classification. The current review discussed the recommended molecular biomarkers and genetic aberrations based on the 2021 WHO classification in adult-type diffuse gliomas, along with associated deregulated miRNAs. Additionally, the study highlights miRNA-based treatment advancements in adults with gliomas.
引用
收藏
页码：141 / 152
页数：12
相关论文
共 153 条
  • [1] MicroRNAs in glioblastoma pathogenesis and therapy: A comprehensive review
    Ahir, Bhavesh K.
    Ozer, Howard
    Engelhard, Herbert H.
    Lakka, Sajani S.
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2017, 120 : 22 - 33
  • [2] Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila
    Ajuria, Leiore
    Nieva, Claudia
    Winkler, Clint
    Kuo, Dennis
    Samper, Nuria
    Jose Andreu, Maria
    Helman, Aharon
    Gonzalez-Crespo, Sergio
    Paroush, Ze'ev
    Courey, Albert J.
    Jimenez, Gerardo
    [J]. DEVELOPMENT, 2011, 138 (05): : 915 - 924
  • [3] Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
    An, Zhenyi
    Aksoy, Ozlem
    Zheng, Tina
    Fan, Qi-Wen
    Weiss, William A.
    [J]. ONCOGENE, 2018, 37 (12) : 1561 - 1575
  • [4] Prognostic relevance of genetic alterations in diffuse lower-grade gliomas
    Aoki, Kosuke
    Nakamura, Hideo
    Suzuki, Hiromichi
    Matsuo, Keitaro
    Kataoka, Keisuke
    Shimamura, Teppei
    Motomura, Kazuya
    Ohka, Fumiharu
    Shiina, Satoshi
    Yamamoto, Takashi
    Nagata, Yasunobu
    Yoshizato, Tetsuichi
    Mizoguchi, Masahiro
    Abe, Tatsuya
    Momii, Yasutomo
    Muragaki, Yoshihiro
    Watanabe, Reiko
    Ito, Ichiro
    Sanada, Masashi
    Yajima, Hironori
    Morita, Naoya
    Takeuchi, Ichiro
    Miyano, Satoru
    Wakabayashi, Toshihiko
    Ogawa, Seishi
    Natsume, Atsushi
    [J]. NEURO-ONCOLOGY, 2018, 20 (01) : 66 - 77
  • [5] MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancer
    Bai, Lin
    Wang, Hui
    Wang, Ai-Hua
    Zhang, Luo-Ying
    Bai, Jie
    [J]. PLOS ONE, 2017, 12 (03):
  • [6] Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies
    Balachandran, Akilandeswari A.
    Larcher, Leon M.
    Chen, Suxiang
    Veedu, Rakesh N.
    [J]. CANCERS, 2020, 12 (09) : 1 - 29
  • [7] Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma
    Bettegowda, Chetan
    Agrawal, Nishant
    Jiao, Yuchen
    Sausen, Mark
    Wood, Laura D.
    Hruban, Ralph H.
    Rodriguez, Fausto J.
    Cahill, Daniel P.
    McLendon, Roger
    Riggins, Gregory
    Velculescu, Victor E.
    Oba-Shinjo, Sueli Mieko
    Marie, Suely Kazue Nagahashi
    Vogelstein, Bert
    Bigner, Darell
    Yan, Hai
    Papadopoulos, Nickolas
    Kinzler, Kenneth W.
    [J]. SCIENCE, 2011, 333 (6048) : 1453 - 1455
  • [8] Simultaneous downregulation of miR-21 and upregulation of miR-7 has anti-tumor efficacy
    Bhere, Deepak
    Arghiani, Nahid
    Lechtich, Esther Revai
    Yao, Yizheng
    Alsaab, Sarah
    Bei, Fengfeng
    Matin, Maryam M.
    Shah, Khalid
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [9] microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis
    Bhere, Deepak
    Tamura, Kaoru
    Wakimoto, Hiroaki
    Choi, Sung Hugh
    Purow, Benjamin
    Debatisse, Jeremy
    Shah, Khalid
    [J]. NEURO-ONCOLOGY, 2018, 20 (02) : 215 - 224
  • [10] Awakening the "guardian of genome": reactivation of mutant p53
    Binayke, Akshay
    Mishra, Sarthak
    Suman, Prabhat
    Das, Suman
    Chander, Harish
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2019, 83 (01) : 1 - 15
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