OPTIMIZATION STUDY AND ANTIMICROBIAL ACTIVITY OF HEXAHYDROACRIDINE-1,8(2H,5H)-DIONE: A PROMISING COMPOUND FOR NOVEL THERAPEUTICS

被引：0
作者：
Patel, Shweta [1 ]
Patel, Sarika [1 ]
Parikh, Jaymin [1 ]
机构：
[1] Ganpat Univ, Mehsana Urban Inst Sci, Fac Sci, Dept Chem, Mehsana 384012, Gujarat, India
来源：
HETEROCYCLIC LETTERS | 2023年 / 13卷 / 03期
关键词：
Hexahydroacridine-1; 8-dione; Morpholine; One pot multi-component reaction; Optimization study; aqueous condition; green chemistry; Antibacterial and Antifungal activity; DERIVATIVES; DICHLORIDES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hexahydroacridine-1,8-dione is a chemical compound that has gained significant attention in medicinal chemistry and drug discovery research. This versatile building block offers a unique molecular structure that serves as a valuable precursor for the synthesis of diverse chemical scaffolds. In this research paper, we explore the synthesis and potential applications of hexahydroacridine-1,8-dione derivatives in the development of novel therapeutic agents. We develop into its pharmacological activities, including antibacterial and antifungal activity. The synthetic derivatives were confirmed using IR, 1H NMR, 13CNMR, mass spectra, and elemental analysis. The use of water as a solvent that is believed to be reasonably environmentally beneficial.
引用
收藏
页码：583 / 590
页数：8
相关论文
共 50 条
  • [21] Synthesis and antimicrobial activity of some 2-[1-(4-oxo-3,4-dihydrophthalazine-1-yl)alkyl]-1H-isoindole-1,3(2H)-dione and their imidoxy derivatives
    Salvi, Vijay K.
    Bhambi, Dinesh
    Jat, Jawahar L.
    Talesara, Ganpat L.
    ARKIVOC, 2006, : 133 - 140
  • [22] Synthesis, single crystal X-ray, DFT, Hirshfeld surface and molecular docking studies of 9-(2,4-dichlorophenyl)-4a-hydroxy-tetramethyl- octahydro-1H-xanthene-1,8(2H)-dione
    Fatima, Aysha
    Khanum, Ghazala
    Sharma, Arun
    Siddiqui, Nazia
    Muthu, S.
    Butcher, R. J.
    Srivastava, Sanjay Kumar
    Javed, Saleem
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1268
  • [23] A facile and simple synthesis of novel isoxazolyl benzo[f][1,4]oxazepin-3-(2H)-ones and their antimicrobial activity
    Kakkerla, Ramu
    Marri, Srinivas
    Krishna, M. P. S. Murali
    Rajam, M. V.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (06): : 823 - 829
  • [24] Synthesis and Study of the Antimicrobial Activity of Novel Tricyclic 2H-pyrimido[2,1-b]benzothiazoles
    Kumbhare, Ravindra M.
    Nagragu, Chinna
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (07) : 633 - 639
  • [25] Isolation, characterization, crystal structure, free radical scavenging- and computational studies of 9-[-4(propan-2-yl)pheny]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione from Garcinia kola seeds
    Agunbiade, Rachael Y.
    Jasinski, Jerry P.
    Millikan, Sean P.
    Sanusi, Kayode
    Yilmaz, Yusuf
    Ceylan, Umit
    Fadare, Olatomide A.
    Obafemi, Craig A.
    JOURNAL OF MOLECULAR STRUCTURE, 2017, 1144 : 396 - 405
  • [26] The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups
    Tan, Ayse
    Kizilkaya, Serap
    Kelestemur, Unzile
    Akdemir, Atilla
    Kara, Yunus
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (11) : 1368 - 1378
  • [27] Atropisomerism in a 10-Membered Ring with Multiple Chirality Axes: (3Z,9Z)-1,2,518-Dithiadiazecine-6,7(5H,8H)-dione Series
    Risso, Vesna
    Farran, Daniel
    Javierre, Guilhem
    Naubron, Jean-Valere
    Giorgi, Michel
    Piras, Patrick
    Jean, Marion
    Vanthuyne, Nicolas
    Fruttero, Roberta
    Lorcy, Dominique
    Roussel, Christian
    JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (15) : 7566 - 7573
  • [28] Synthesis and antimicrobial activity of novel 5-[(1H-indol-3-yl)methylene]thiazolidine-2,4-dione-[1,2,3]triazole hybrids
    Kamala, L.
    Veena, B. S.
    Lakshmi, P. V. Anantha
    Vasantha, P.
    Sujatha, E.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (02) : 316 - 321
  • [29] Synthesis and antimicrobial activity of some novel substituted pyridazin-3(2H)-ones containing 1,3,4-thiadiazole moiety
    Sallam, Mohammed S.
    El-Hashash, Maher A.
    Guirguis, Dalal B.
    MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (02) : 369 - 380
  • [30] Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4 (2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study
    Bhalodiya, Savan S.
    Parmar, Mehul P.
    Upadhyay, Dipti B.
    Patel, Chirag D.
    Vala, Disha P.
    Rajani, Dhanji
    Patel, Hitendra M.
    RESULTS IN CHEMISTRY, 2024, 7
12345