Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice

被引：5

作者：

Zhang, Yong-Qing ^{[1
]}

Min, Hyun Kyu ^{[1
]}

Hong, Eunchong ^{[1
]}

Yu, Eunhye ^{[1
]}

Gu, Sun Mi ^{[1
]}

Yoon, Seong Shoon ^{[2
]}

Lee, Dohyun ^{[3
]}

Lee, Jaejun ^{[3
]}

Hong, Jin Tae ^{[1
]}

Yun, Jaesuk ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, 194-31 Osongsaengmyeong 1 Ro, Cheongju 28160, Chungcheongbuk, South Korea

[2] Daegu Haany Univ, Coll Korean Med, 136 Sincheondong Ro, Daegu 42158, South Korea

[3] Osong Med Innovat Fdn, Lab Anim Ctr, 123 Osongsaengmyung Ro, Cheongju 28160, Chungcheongbuk, South Korea

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 169卷

基金：

新加坡国家研究基金会;

关键词：

Intracranial self -stimulation; Dopamine transporter; Medial prefrontal cortex; Nucleus accumbens; Dopamine; BRAIN; METHYLPHENIDATE; RELEASE;

D O I：

10.1016/j.biopha.2023.115860

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intracranial self-stimulation (ICSS) of the medial forebrain bundle in mice is an experimental model use to assess the relative potential of reward-seeking behaviors. Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alphaPyrrolidinobutyrophenone (alpha-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; paramethoxymethamphetamine (PMMA); phendimetrazine; N-(1-adamantyl)-1-pentyl-1H-indazole-3carboxamide (AKB-48); Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (CB-13); 4-Ethylnaphthalen-1yl-(1-pentylindol-3-yl)methanone (JWH-210); Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018); N(ortho-methoxybenzyl)-4-ethylamphetamine (4-EA-NBOMe); N-[(2-Methoxyphenyl)methyl]-N-methyl-1-(4methylphenyl)propan-2-amine (4-MMA-NBOMe); and 1-[1-(4-methoxyphenyl)cyclohexyl]piperidine (4-MeOPCP). We determined dopamine transporter (DAT) availability in the medial prefrontal cortex (mPFC), striatum, and nucleus accumbens (NAc) after drug treatment. DAT availability in the mPFC and NAc significantly correlated with the ICSS threshold after drug treatment. Extracellular dopamine and calcium levels in PC-12 cells were measured following drug treatment. After drug treatment, Spearman rank and Pearson correlation analyses showed a significant difference between the extracellular dopamine level and the ICSS threshold. After drug treatment, Spearman rank correlation analysis showed a significant correlation between Ca2+ signaling and the ICSS threshold. A positive correlation exists between the ICSS threshold and DAT availability in the mPFC and NAc provoked by abused drugs. The relative potential of drug-induced reward-seeking behavior may be related to DAT availability-mediated extracellular dopamine levels in the mPFC and NAc.

引用

页数：10

共 22 条

[21] 6-Hydroxydopamine-Induced Dopamine Reductions in the Nucleus Accumbens, but not the Medial Prefrontal Cortex, Impair Cincinnati Water Maze Egocentric and Morris Water Maze Allocentric Navigation in Male Sprague–Dawley Rats
Amanda A. Braun
Robyn M. Amos-Kroohs
Arnold Gutierrez
Kerstin H. Lundgren
Kim B. Seroogy
Charles V. Vorhees
Michael T. Williams
Neurotoxicity Research, 2016, 30 : 199 - 212
[22] 6-Hydroxydopamine-Induced Dopamine Reductions in the Nucleus Accumbens, but not the Medial Prefrontal Cortex, Impair Cincinnati Water Maze Egocentric and Morris Water Maze Allocentric Navigation in Male Sprague-Dawley Rats
Braun, Amanda A.
Amos-Kroohs, Robyn M.
Gutierrez, Arnold
Lundgren, Kerstin H.
Seroogy, Kim B.
Vorhees, Charles V.
Williams, Michael T.
NEUROTOXICITY RESEARCH, 2016, 30 (02) : 199 - 212

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