CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

被引：7

作者：

Takasugi, Masaki ^{[1
,2
]}

Ohtani, Naoko ^{[2
]}

Takemura, Kazuaki ^{[2
]}

Emmrich, Stephan ^{[1
]}

Zakusilo, Frances T. ^{[1
]}

Yoshida, Yuya ^{[2
]}

Kutsukake, Nobuyuki ^{[3
]}

Mariani, John N. ^{[4
,5
]}

Windrem, Martha S. ^{[4
,5
]}

Chandler-Militello, Devin ^{[4
,5
]}

Goldman, Steven A. ^{[4
,5
]}

Satoh, Junko ^{[6
]}

Ito, Shinji ^{[6
]}

Seluanov, Andrei ^{[1
]}

Gorbunova, Vera ^{[1
,7
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[2] Osaka Metropolitan Univ, Grad Sch Med, Dept Pathophysiol, Osaka, Japan

[3] Grad Univ Adv Studies, Res Ctr Integrat Evolutionary Sci, SOKENDAI, Hayama, Kanagawa, Japan

[4] Univ Rochester, Med Ctr, Ctr Translat Neuromed, Rochester, NY 14642 USA

[5] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA

[6] Kyoto Univ, Med Res Support Ctr, Grad Sch Med, Kyoto, Japan

[7] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA

来源：

CELL REPORTS | 2023年 / 42卷 / 09期

基金：

美国国家卫生研究院;

关键词：

OLIGODENDROCYTE PROGENITOR CELLS; WHITE-MATTER; LUMINAL DOMAIN; IN-VITRO; CNS; IDENTIFICATION; DISSOCIATION; POPULATION; INSIGHTS; REPAIR;

D O I：

10.1016/j.celrep.2023.113130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR's resistance to neurodegenerative diseases remain elusive. Here, we isolated oligodendrocyte progenitor cells (OPCs) from NMRs and compared their transcriptome with that of other mammals. Extracellular matrix (ECM) genes best distinguish OPCs of long-and short-lived species. Notably, expression levels of CD44, an ECM-binding protein that has been suggested to contribute to NMR longevity by mediating the effect of hyaluronan (HA), are not only high in OPCs of long-lived species but also positively correlate with longevity in multiple cell types/tissues. We found that CD44 localizes to the endoplasmic reticulum (ER) and enhances basal ATF6 activity. CD44 modifies proteome and membrane properties of the ER and enhances ER stress resistance in a manner dependent on unfolded protein response regulators without the requirement of HA. HA-independent role of CD44 in proteostasis regulation may contribute to mammalian longevity.

引用

页数：23

共 82 条

[1] Accelerated evolution of oligodendrocytes in the human brain [J].

Berto, Stefano ;

Mendizabal, Isabel ;

Usui, Noriyoshi ;

Toriumi, Kazuya ;

Chatterjee, Paramita ;

Douglas, Connor ;

Tamminga, Carol A. ;

Preuss, Todd M. ;

Yi, Soojin V. ;

Konopka, Genevieve .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (48) :24334-24342

[2] Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis [J].

Blackwood, Erik A. ;

Azizi, Khalid ;

Thuerauf, Donna J. ;

Paxman, Ryan J. ;

Plate, Lars ;

Kelly, Jeffery W. ;

Wiseman, R. Luke ;

Glembotski, Christopher C. .

NATURE COMMUNICATIONS, 2019, 10 (1)

[3] Trimmomatic: a flexible trimmer for Illumina sequence data [J].

Bolger, Anthony M. ;

Lohse, Marc ;

Usadel, Bjoern .

BIOINFORMATICS, 2014, 30 (15) :2114-2120

[4] Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species [J].

Buffenstein, Rochelle .

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY, 2008, 178 (04) :439-445

[5] Enrichr: interactive and collaborative HTML']HTML5 gene list enrichment analysis tool [J].

Chen, Edward Y. ;

Tan, Christopher M. ;

Kou, Yan ;

Duan, Qiaonan ;

Wang, Zichen ;

Meirelles, Gabriela Vaz ;

Clark, Neil R. ;

Ma'ayan, Avi .

BMC BIOINFORMATICS, 2013, 14

[6] The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi [J].

Chen, X ;

Shen, J ;

Prywes, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) :13045-13052

[7] Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization [J].

Counter, CM ;

Hahn, WC ;

Wei, WY ;

Caddle, SD ;

Beijersbergen, RL ;

Lansdorp, PM ;

Sedivy, JM ;

Weinberg, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14723-14728

[8] The content and size of hyaluronan in biological fluids and tissues [J].

Cowman, Mary K. ;

Lee, Hong-Gee ;

Schwertfeger, Kathryn L. ;

McCarthy, James B. ;

Turley, Eva A. .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[9]

Cyphert Jaime M, 2015, Int J Cell Biol, V2015, P563818, DOI 10.1155/2015/563818

[10] UPRER promotes lipophagy independent of chaperones to extend life span [J].

Daniele, Joseph R. ;

Higuchi-Sanabria, Ryo ;

Durieux, Jenni ;

Monshietehadi, Samira ;

Ramachandran, Vidhya ;

Tronnes, Sarah U. ;

Kelet, Naame ;

Sanchez, Melissa ;

Metcalf, Melissa G. ;

Garcia, Gilberto ;

Frankino, Phillip A. ;

Benitez, Camila ;

Zeng, Mandy ;

Esping, Daniel J. ;

Joe, Larry ;

Dillin, Andrew .

SCIENCE ADVANCES, 2020, 6 (01)

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