Triglycerides, Obesity and Education Status Are Associated with the Risk of Developing Type 2 Diabetes in Young Adults, Cohort Study

被引:2
作者
Garbuzova, Evgeniia V. [1 ]
Shcherbakova, Lilia V. [1 ]
Rymar, Oksana D. [1 ]
Khudiakova, Alyona D. [1 ]
Shramko, Victoria S. [1 ]
Ragino, Yulia I. [1 ]
机构
[1] Russian Acad Sci IIPM Branch IC&G SB RAS, Siberian Branch, Res Inst Internal & Prevent Med, Branch Inst Cytol & Genet, Novosibirsk 630089, Russia
关键词
cohort study; persons 25-44 years old; type 2 diabetes mellitus; obesity; hypertriglyceridemia; educational status; CARDIOVASCULAR-DISEASE; GLOBAL BURDEN; MELLITUS; PREVALENCE; PROJECTIONS; POPULATION; COUNTRIES; REGISTER; THERAPY;
D O I
10.3390/jpm13091403
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: It is important to determine the influence of traditional risk factors on the development of type 2 diabetes mellitus (T2DM) in young adults. Goal of the research: To study the incidence of T2DM and factors that increase the risk of its occurrence during the observation of a cohort of young adults. Materials and methods: 1341 people aged 25-44 were included in the study from 2013 to 2017, of whom 622 were men (46.4%). The examination included anamnesis, anthropometric data, and a blood test. Cases of developed T2DM were identified by comparing the Diabetes Mellitus Register, medical records of patients, and the database of examined individuals from 2019 to 2023. T2DM Results: In the examined population, 11 participants (0.82%) developed T2DM. The prevalence of T2DM was 0.96% in men and 0.69% in women. Patients with T2DM had a higher waist circumference, BMI, SBP, TG, and lower HDL than patients without T2DM, and were also less likely to have a higher education. The risk of developing T2DM increases 6.5 times at a BMI of & GE;30 kg/m2, and 5.2 times at a TG level of & GE;1.7 mmol/L, regardless of other risk factors. In the absence of a higher education, the risk of developing T2DM is increased by 5.6 times. Conclusion: In young people, high triglyceride levels, obesity, and a low level of education are associated with the risk of developing type 2 diabetes, regardless of other factors.
引用
收藏
页数:10
相关论文
共 34 条
[1]   Burden of type 2 diabetes attributed to lower educational levels in Sweden [J].
Agardh, Emilie E. ;
Sidorchuk, Anna ;
Hallqvist, Johan ;
Ljung, Rickard ;
Peterson, Stefan ;
Moradi, Tahereh ;
Allebeck, Peter .
POPULATION HEALTH METRICS, 2011, 9
[2]   Mechanism linking diabetes mellitus and obesity [J].
Al-Goblan, Abdullah S. ;
Al-Alfi, Mohammed A. ;
Khan, Muhammad Z. .
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2014, 7 :587-591
[3]   Body composition changes in diabetes and aging [J].
Al-Sofiani, Mohammed E. ;
Ganji, Suneeta S. ;
Kalyani, Rita R. .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2019, 33 (06) :451-459
[4]   Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].
Alberti, K. G. M. M. ;
Eckel, Robert H. ;
Grundy, Scott M. ;
Zimmet, Paul Z. ;
Cleeman, James I. ;
Donato, Karen A. ;
Fruchart, Jean-Charles ;
James, W. Philip T. ;
Loria, Catherine M. ;
Smith, Sidney C., Jr. .
CIRCULATION, 2009, 120 (16) :1640-1645
[5]   Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study [J].
Beshara, Amani ;
Cohen, Eytan ;
Goldberg, Elad ;
Lilos, Pearl ;
Garty, Moshe ;
Krause, Ilan .
JOURNAL OF INVESTIGATIVE MEDICINE, 2016, 64 (02) :383-387
[6]   MECHANISMS OF FATTY ACID-INDUCED INHIBITION OF GLUCOSE-UPTAKE [J].
BODEN, G ;
CHEN, XH ;
RUIZ, J ;
WHITE, JV ;
ROSSETTI, L .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2438-2446
[7]   Obesity and Free Fatty Acids [J].
Boden, Guenther .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2008, 37 (03) :635-+
[8]   Comparison of β-Cell Function Between Overweight/Obese Adults and Adolescents Across the Spectrum of Glycemia [J].
Chen, Melinda E. ;
Chandramouli, Aaditya G. ;
Considine, Robert V. ;
Hannon, Tamara S. ;
Mather, Kieren J. .
DIABETES CARE, 2018, 41 (02) :318-325
[9]   The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study) [J].
Dedov, I. I. ;
Shestakova, M. V. ;
Galstyan, G. R. .
DIABETES MELLITUS, 2016, 19 (02) :104-112
[10]   STANDARDS OF SPECIALIZED DIABETES CARE [J].
Dedov, I. I. ;
Shestakova, M., V .
DIABETES MELLITUS, 2013, 16 :1-119