Structural analysis of a hormone-bound Striga strigolactone receptor

被引：4
作者：
Arellano-Saab, Amir [1 ,2 ]
Skarina, Tatiana [2 ]
Xu, Zhenhua [1 ]
McErlean, Christopher S. P. [3 ]
Savchenko, Alexei [2 ,4 ]
Lumba, Shelley [1 ]
Stogios, Peter J. J. [2 ]
McCourt, Peter [1 ]
机构：
[1] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada
[2] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON, Canada
[3] Univ Sydney, Sch Chem, Sydney, NSW, Australia
[4] Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada
来源：
NATURE PLANTS | 2023年 / 9卷 / 06期
基金：
加拿大自然科学与工程研究理事会;
关键词：
RECOGNITION; DWARF14; LIGAND;
D O I：
10.1038/s41477-023-01423-y
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Strigolactones (SLs) regulate many aspects of plant development, but ambiguities remain about how this hormone is perceived because SL-complexed receptor structures do not exist. We find that when SL binds the Striga receptor, ShHTL5, a series of conformational changes relative to the unbound state occur, but these events are not sufficient for signalling. Ligand-complexed receptors, however, form internal tunnels that posit an explanation for how SL exits its receptor after hydrolysis. Strigolactone (SL) regulates plant development. Structural analysis shows that when SL binds its receptor ShHTL5, conformational changes occur including the creation of internal tunnels that posit an explanation for how SL by-products exit the receptor after signalling.
引用
收藏
页码：883 / +
页数：11
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