Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

被引：3

作者：

Biagiotti, Giacomo ^{[1
]}

Toniolo, Gianluca ^{[1
,2
]}

Albino, Martin ^{[1
,3
]}

Severi, Mirko ^{[1
]}

Andreozzi, Patrizia ^{[1
]}

Marelli, Marcello ^{[4
]}

Kokot, Hana ^{[5
]}

Tria, Giancarlo ^{[1
]}

Guerri, Annalisa ^{[1
]}

Sangregorio, Claudio ^{[3
]}

Rojo, Javier ^{[6
]}

Berti, Debora ^{[1
,7
]}

Marradi, Marco ^{[1
]}

Cicchi, Stefano ^{[1
,2
]}

Urbancic, Iztok ^{[5
]}

van Kooyk, Yvette ^{[8
]}

Chiodo, Fabrizio ^{[8
,9
]}

Richichi, Barbara ^{[1
,2
]}

机构：

[1] Univ Firenze, Dept Chem Ugo Schiff, Via Lastruccia 13, I-50019 Florence, Italy

[2] Consorzio Interuniv Nazl Sci & Tecnol Materiali IN, I-50121 Florence, Italy

[3] CNR, ICCOM, Via Madonna Piano 10, I-50019 Florence, Italy

[4] CNR, Ist Sci & Tecnol Chim Giulio Natta, SCITEC, Via G Fantoli 16-15, I-20138 Milan, Italy

[5] Jozef Stefan Inst, Condensed Matter Phys Dept, Lab Biophys, Jamova C 39, Ljubljana 1000, Slovenia

[6] Univ Seville, CSIC, Inst Invest Quim IIQ, Glycosystems Lab, Av Americo Vespucio 49, Seville 41092, Spain

[7] Italian Ctr Colloid & Surface Sci CSGI, I-50019 Florence, Italy

[8] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Infect & Immun Inst, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

[9] CNR, Natl Res Council, Inst Biomol Chem, Pozzuoli, Napoli, Italy

来源：

NANOSCALE HORIZONS | 2023年 / 8卷 / 06期

关键词：

DC-SIGN;

D O I：

10.1039/d3nh00063j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

引用

页码：776 / 782

页数：7

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