Palladium-Catalyzed C7-H (Hetero)arylation of Pyrazolo[1,5-a ]pyrazines with Heteroarenes and Aryl Iodides with the Assistance of Silver Salts

被引：2

作者：

Nguyen, Thanh V. Q. ^{[1
]}

Levoin, Armand ^{[1
,2
]}

Poli, Lorenzo ^{[1
,2
]}

机构：

[1] AstraZeneca, Med Chem Res & Early Dev Resp & Immunol, BioPharmaceut R&D, Gothenburg, Sweden

[2] Univ Strasbourg, 4 Rue Blaise Pascal, F-67081 Strasbourg, France

来源：

SYNTHESIS-STUTTGART | 2023年 / 55卷 / 21期

关键词：

C-H bond functionalization; fused-ring systems; heteroarenes; homogeneous catalysis; synthetic methods; H BOND FUNCTIONALIZATION; DIRECT ARYLATION; ACTIVATION; BROMIDES; TOOLS;

D O I：

10.1055/s-0041-1738433

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrazolo[1,5-a]pyrazines coupled with heteroarenes and aryl iodides selectively at the C7 position to afford a broad library of bi(hetero)aryl structures under ligand-free palladium-catalyzed conditions. The key to the success of the reaction is the use of silver salts as the oxidant or the base, allowing the regioselective C-H bond functionalization to occur under relatively mild conditions.

引用

页码：3526 / 3534

页数：9

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