Citalopram in the treatment of elderly chronic heart failure combined with depression: A systematic review and meta-analysis

被引:4
|
作者
Yan, Longmei [1 ,2 ,3 ]
Ai, Yuzhen [4 ]
Xing, Yaxuan [1 ,2 ]
Wang, Biqing [1 ,2 ,3 ]
Gao, Anran [1 ,2 ,3 ]
Xu, Qiwu [1 ,2 ,3 ]
Li, Hongzheng [1 ,2 ,3 ]
Chen, Keji [1 ,2 ]
Zhang, Jingchun [1 ,2 ]
机构
[1] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China
[2] China Acad Chinese Med Sci, Xiyuan Hosp, Natl Clin Res Ctr Chinese Med Cardiol, Beijing, Peoples R China
[3] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
[4] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 2, Guiyang, Guizhou, Peoples R China
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷
基金
中国国家自然科学基金;
关键词
citalopram; elderly chronic heart failure; depression; systematic review; meta-analysis; SEROTONIN REUPTAKE INHIBITOR; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; RISK; MORTALITY; DISORDER; HOSPITALIZATION; ANTIDEPRESSANT; ASSOCIATIONS; ESCITALOPRAM;
D O I
10.3389/fcvm.2023.1107672
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundDepression is an independent factor to predict the hospitalization and mortality in the chronic HF patients. Citalopram is known as an effective drug for depression treatment. Currently, there is no specific recommendation in the HF guidelines for the treatment of psychological comorbidity. In recent years, many studies have shown that the citalopram may be safe in treating of chronic HF with depression. ObjectiveTo evaluate the efficacy and safety of the citalopram in the treatment of elderly chronic HF combined with depression. MethodsPubMed, EMBASE, Cochrane, Web of Science, CNKI, VIP, CBM, and Wanfang were searched from their inception to May 2022. In the treatment of elderly chronic HF combined with depression, randomized controlled studies of the citalopram were included. Independent screening and extraction of data information were conducted by two researchers, and the quality was assessed by the Cochrane bias risk assessment tool. Review manager 5.4.1 was employed for statistical analysis. ResultsThe results of meta-analysis prove that the citalopram treatment for depressed patients with chronic HF has a benefit for HAMD-24 (MD: -8.51, 95% CI: -10.15 to -6.88) and LVEF (MD: 2.42, 95% CI: 0.51 to 4.33). Moreover, the score of GDS decreases, and NT-proBNP (MD: -537.78, 95% CI: -718.03 to -357.54) is improved. However, the comparison with the control group indicates that there is no good effect on HAMD-17 (MD: -5.14, 95% CI: -11.60 to 1.32), MADRS (MD: -1.57, 95% CI: -3.47 to 0.32) and LVEDD (MD: -1.45, 95% CI: -3.65 to -0.76). No obvious adverse drug reactions were observed. ConclusionCitalopram treatment for depressed patients with chronic HF has a positive effect on LVEF and NT-proBNP. It can alleviate HAMD-24 and GDS, but the relative benefits for LVEDD, HAMD-17 and MADRS still need to be verified.Systematic Review Registration: PROSPERO [CRD42021289917].
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页数:10
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