Neuroprotective Effect of Melatonin on Sleep Disorders Associated with Parkinson's Disease

被引:16
作者
Hu, Xinyu [1 ]
Li, Jingwen [1 ]
Wang, Xinyi [1 ]
Liu, Hanshu [1 ]
Wang, Tao [1 ]
Lin, Zhicheng [2 ]
Xiong, Nian [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurol, Wuhan 430022, Peoples R China
[2] Harvard Med Sch, McLean Hosp, Lab Psychiat Neurogenom, Belmont, MA 02478 USA
基金
中国国家自然科学基金;
关键词
Parkinson's disease; melatonin; sleep disorders; mechanisms; clinical trials; EXCESSIVE DAYTIME SLEEPINESS; RESTLESS LEGS SYNDROME; BEHAVIOR DISORDER; DOUBLE-BLIND; EXOGENOUS MELATONIN; ALPHA-SYNUCLEIN; CONTROLLED-TRIAL; LIGHT THERAPY; MODEL; APNEA;
D O I
10.3390/antiox12020396
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Parkinson's disease (PD) is a complex, multisystem disorder with both neurologic and systemic manifestations, which is usually associated with non-motor symptoms, including sleep disorders. Such associated sleep disorders are commonly observed as REM sleep behavior disorder, insomnia, sleep-related breathing disorders, excessive daytime sleepiness, restless legs syndrome and periodic limb movements. Melatonin has a wide range of regulatory effects, such as synchronizing circadian rhythm, and is expected to be a potential new circadian treatment of sleep disorders in PD patients. In fact, ongoing clinical trials with melatonin in PD highlight melatonin's therapeutic effects in this disease. Mechanistically, melatonin plays its antioxidant, anti-inflammatory, anti-excitotoxity, anti-synaptic dysfunction and anti-apoptotic activities. In addition, melatonin attenuates the effects of genetic variation in the clock genes of Baml1 and Per1 to restore the circadian rhythm. Together, melatonin exerts various therapeutic effects in PD but their specific mechanisms require further investigations.
引用
收藏
页数:23
相关论文
共 50 条
[41]   Sleep Disorders in Parkinson Disease [J].
Stefani, Ambra ;
Hoegl, Birgit .
SLEEP MEDICINE CLINICS, 2021, 16 (02) :323-334
[42]   Sleep and sleep disorders in people with Parkinson's disease [J].
Iranzo, Alex ;
De Cock, Valerie Cochen ;
Fantini, Maria Livia ;
Perez-Carbonell, Laura ;
Trotti, Lynn Marie .
LANCET NEUROLOGY, 2024, 23 (09) :925-937
[43]   Effects of rotigotine on Parkinson's disease-related sleep disturbances [J].
Antonini, Angelo ;
Calandrella, Daniela ;
Merello, Marcelo ;
Koutsikos, Konstantinos ;
Pilleri, Manuela .
EXPERT OPINION ON PHARMACOTHERAPY, 2013, 14 (18) :2571-2580
[44]   Neuroprotective Potential of Melatonin: Evaluating Therapeutic Efficacy in Alzheimer's and Parkinson's Diseases [J].
Talbot, Norris C. ;
Luther, Patrick M. ;
Spillers, Noah J. ;
Ragland, Amanda R. ;
Kidder, Evan J. ;
Kelkar, Rucha A. ;
Varrassi, Giustino ;
Ahmadzadeh, Shahab ;
Shekoohi, Sahar ;
Kaye, Alan D. .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (12)
[45]   Associations of Sleep Disorders With Depressive Symptoms in Early and Prodromal Parkinson's Disease [J].
Ma, Jiangnan ;
Dou, Kaixin ;
Liu, Ruize ;
Liao, Yajin ;
Yuan, Zengqiang ;
Xie, Anmu .
FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
[46]   Sleep disorders and the natural history of Parkinson's disease: The contribution of epidemiological studies [J].
Zoccolella, Stefano ;
Savarese, Mariantonietta ;
Lamberti, Paolo ;
Manni, Raffaele ;
Pacchetti, Claudio ;
Logroscino, Giancarlo .
SLEEP MEDICINE REVIEWS, 2011, 15 (01) :41-50
[47]   Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease [J].
Taximaimaiti, Reyisha ;
Luo, Xingguang ;
Wang, Xiao-Ping .
CURRENT NEUROPHARMACOLOGY, 2021, 19 (12) :2233-2249
[48]   Sleep disorders in patients with Parkinson's disease [J].
Martinez Martin, Pablo ;
Rodriguez Blazquez, Carmen .
SALUD I CIENCIA, 2009, 17 (01) :25-28
[49]   Clinical characteristics of sleep disorders in patients with Parkinson's disease [J].
Mao, Zhi-juan ;
Liu, Chan-chan ;
Ji, Su-qiong ;
Yang, Qing-mei ;
Ye, Hong-xiang ;
Han, Hai-yan ;
Xue, Zheng .
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2017, 37 (01) :100-104
[50]   Role of sleep and sleep disorders on motor and nonmotor features of Parkinson's Disease [J].
Korkmaz, Bektas ;
Yildiz, Busra ;
Senel, Gulcin Benbir ;
Karadeniz, Derya .
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, 2021, 38 (01) :20-27