Targeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It

被引：16

作者：

Chen, Cong ^{[1
]}

Ye, Qianwei ^{[1
]}

Wang, Linbo ^{[2
]}

Zhou, Jichun ^{[2
]}

Xiang, Aizhai ^{[1
]}

Lin, Xia ^{[1
]}

Guo, Jufeng ^{[1
]}

Hu, Shufang ^{[1
]}

Rui, Tao ^{[1
]}

Liu, Jian ^{[1
]}

机构：

[1] Zhejiang Univ Sch Med, Affiliated Hangzhou Peoples Hosp 1, Dept Breast Surg, Hangzhou, Peoples R China

[2] Zhejiang Univ Sch Med, Sir Run Run Shaw Hosp, Dept Surg Oncol, Hangzhou, Peoples R China

来源：

CELL DEATH DISCOVERY | 2023年 / 9卷 / 01期

基金：

英国科研创新办公室;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; CELL-DEATH; GASDERMIN D; INFLAMMATORY CASPASES; NLRP3; INFLAMMASOME; SIGNALING PATHWAY; DOWN-REGULATION; EXPRESSION; TUMOR; METHYLATION;

D O I：

10.1038/s41420-023-01370-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumors and can serve as a new strategy for cancer treatment. Here, we present a basic knowledge of pyroptosis, and an overview of the expression patterns and roles of GSDMs in breast cancer. In addition, we further summarize the available evidence of pyroptosis in breast cancer progression and give insight into the clinical potential of applying pyroptosis in anticancer strategies for breast cancer. This review will deepen our understanding of the relationship between pyroptosis and breast cancer, and provide a novel potential therapeutic avenue for breast cancer.

引用

页数：10

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