A decrease in newly diagnosed patients with adult T-cell leukemia/lymphoma in Kagoshima, a highly endemic area of HTLV-1 in southwestern Japan

被引：2

作者：

Owatari, Satsuki ^{[1
]}

Tokunaga, Masahito ^{[2
]}

Nakamura, Daisuke ^{[3
]}

Uozumi, Kimiharu ^{[4
]}

Sagara, Yasuko ^{[5
]}

Nakamura, Hitomi ^{[5
]}

Haraguchi, Koichi ^{[1
]}

Nakano, Nobuaki ^{[2
]}

Yoshimitsu, Makoto ^{[3
]}

Ito, Yoshikiyo ^{[2
]}

Utsunomiya, Atae ^{[2
]}

Otsuka, Maki ^{[1
]}

Hanada, Shuichi ^{[1
]}

Iwanaga, Masako ^{[6
]}

Ishitsuka, Kenji ^{[3
,7
]}

机构：

[1] Natl Hosp Org Kagoshima Med Ctr, Dept Hematol, Kagoshima, Japan

[2] Imamura Gen Hosp, Dept Hematol, Kagoshima, Japan

[3] Kagoshima Univ, Dept Hematol & Rheumatol, Kagoshima, Japan

[4] Natl Hosp Org Kagoshima Med Ctr, Dept Med Oncol, Kagoshima, Japan

[5] Japanese Red Cross Kyushu Block Blood Ctr, Dept Qual, Fukuoka, Japan

[6] Japanese Red Cross Nagasaki Genbaku Hosp, Dept Med Technol, Nagasaki, Japan

[7] Kagoshima Univ, Dept Hematol & Rheumatol, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 04期

关键词：

HTLV-1; seropositivity; ATL; incidence; LYMPHOTROPIC VIRUS TYPE-1; LEUKEMIA-LYMPHOMA; BLOOD DONORS; TRANSMISSION; NATIONWIDE; INFECTION; FEATURES; RISK; MILK; ATL;

D O I：

10.1080/10428194.2023.2173524

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type-I (HTLV-1). This study investigated whether the number of newly diagnosed patients with ATL is decreasing in the background of a declining number of individuals infected by HTLV-1 in Kagoshima, Japan, one of the most endemic areas of HTLV-1 in the world. We retrospectively analyzed the number of newly diagnosed patients with ATL between January 2001 and December 2021 in three major hospitals. The number of newly diagnosed patients with B-cell non-Hodgkin lymphoma (B-NHL) in the same period was examined as an internal control. One thousand eighteen and 2,029 patients with ATL and B-NHL were registered, respectively. The age-adjusted incidence of ATL steadily increased between 2001 and 2012, whereas that between 2013 and 2021 decreased. Despite the limitation of its retrospective nature, this is the first report indicating a decrease in ATL patients in Japan.

引用

页码：865 / 873

页数：9

共 33 条

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