The biology of TREM receptors

被引：147
作者：
Colonna, Marco [1 ]
机构：
[1] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63130 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2023年 / 23卷 / 9期
基金：
美国国家卫生研究院;
关键词：
MYELOID CELLS-1 TREM-1; TUMOR-ASSOCIATED MACROPHAGES; IMPROVES HOST-DEFENSE; CUTTING EDGE; SINGLE-CELL; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; AMPLIFIES INFLAMMATION; ACTIVATING RECEPTOR; PATTERN-RECOGNITION;
D O I：
10.1038/s41577-023-00837-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology. In this Review, Marco Colonna provides a comprehensive summary of the triggering receptor expressed on myeloid cells (TREM) family of receptors. TREMs are important for modulating signalling in myeloid cells and have now been implicated in many different disease settings, including inflammatory diseases, autoimmunity, neurodegeneration and cancer.
引用
收藏
页码：580 / 594
页数：15
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