Natural compounds regulate the PI3K/Akt/GSK3β pathway in myocardial ischemia-reperfusion injury

被引：27
作者：
Ajzashokouhi, Amir Hossein [1 ]
Rezaee, Ramin [2 ,3 ]
Omidkhoda, Navid [4 ]
Karimi, Gholamreza [5 ,6 ,7 ]
机构：
[1] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[2] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran
[3] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran
[5] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran
[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
[7] Mashhad Univ Med Sci, Inst Pharmaceut Technol, Pharmaceut Res Ctr, Mashhad, Iran
来源：
CELL CYCLE | 2023年 / 22卷 / 07期
关键词：
PI3K/Akt/GSK3 beta pathway; ischemia-reperfusion; injury; cardiomyocyte; natural compounds; apoptosis; ACTIVATED PROTEIN-KINASE; INDUCED CARDIAC-HYPERTROPHY; GLYCOGEN-SYNTHASE KINASE-3-BETA; PERMEABILITY TRANSITION PORE; COLON-CANCER CELLS; SALVIANOLIC ACID B; PROLONGS LIFE-SPAN; HIGH-FAT DIET; ISCHEMIA/REPERFUSION INJURY; ASTRAGALOSIDE-IV;
D O I：
10.1080/15384101.2022.2161959
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The PI3K/Akt/GSK3 beta pathway is crucial in regulating cardiomyocyte growth and survival. It has been shown that activation of this pathway alleviates the negative impact of ischemia-reperfusion. Glycogen synthase kinase-3 (GSK3 beta) induces apoptosis through stimulation of transcription factors, and its phosphorylation has been suggested as a new therapeutic target for myocardial ischemia-reperfusion injury (MIRI). GSK3 beta regulatory role is mediated by the reperfusion injury salvage kinase (RISK) pathway, and its inhibition by Akt activation blocks mitochondrial permeability transition pore (mPTP) opening and enhances myocardial survival. The present article discusses the involvement of the PI3K/Akt/GSK3 beta pathway in cardioprotective effects of natural products against MIRI.
引用
收藏
页码：741 / 757
页数：17
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