Tiny Drosophila intestinal stem cells, big power

被引：2
|
作者：
Zhai, Jingbo [1 ,2 ,3 ]
Li, Wanyang [1 ]
Liu, Xin [1 ,2 ,3 ]
Wang, Di [1 ,2 ,3 ]
Zhang, Dongli [1 ,2 ,3 ]
Liu, Yanli [4 ]
Liang, Xiuwen [5 ]
Chen, Zeliang [1 ,2 ,3 ]
机构：
[1] Inner Mongolia Minzu Univ, Med Coll, Tongliao 028000, Peoples R China
[2] Key Lab Zoonose Prevent & Control Univ Inner Mong, Tongliao, Peoples R China
[3] Brucellosis Prevent & Treatment Engn Res Ctr Inne, Tongliao, Peoples R China
[4] Inner Mongolia Minzu Univ, Affiliated Hosp, Tongliao, Peoples R China
[5] Hulunbuir City Peoples Hosp, Hulunbuir City 021008, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2023年 / 47卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Drosophila; microbiota; midgut; signaling crosstalk; stem cells; TISSUE HOMEOSTASIS; HIPPO PATHWAY; DUAL OXIDASE; LIFE-SPAN; PROLIFERATION; MIDGUT; DIVISION; GUT; DIFFERENTIATION; GROWTH;
D O I：
10.1002/cbin.11911
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The signaling pathways are highly conserved between Drosophila and mammals concerning intestinal development, regeneration, and disease. The powerful genetic tools of Drosophila make it a valuable and convenient alternative to answer basic biological questions that can not be addressed using mammalian models. In this review, we discuss recent advances in how we use fly midgut to answer the following key questions: (1) How intestine stem cell niches are established; (2) which factors control asymmetric division of stem cells; (3) how intestinal cells interact with environmental factors, such as tissue damage, microbiota, and diet; (4) how to screen aging/cancer-related factors or drugs by fly intestine stem cells.
引用
收藏
页码：3 / 14
页数：12
相关论文
共 50 条
  • [31] TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila
    Strilbytska, Olha M.
    Storey, Kenneth B.
    Lushchak, Oleh, V
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2020, 243
  • [32] Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells
    Park, Joung-Sun
    Kim, Yung-Jin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (10)
  • [33] Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells
    Amcheslavsky, Alla
    Ito, Naoto
    Jiang, Jin
    Ip, Y. Tony
    JOURNAL OF CELL BIOLOGY, 2011, 193 (04) : 695 - 710
  • [34] Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
    Zhao, Liusha
    Luo, Ting
    Zhang, Hong
    Fan, Xinxin
    Zhang, Qiaoqiao
    Chen, Haiyang
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2024, 12
  • [35] Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism
    Wisidagama, Dona R.
    Thummel, Carl S.
    G3-GENES GENOMES GENETICS, 2019, 9 (11): : 3623 - 3630
  • [36] An amuse-bouche of stem cell regulation: Underlying principles and mechanisms from adult Drosophila intestinal stem cells
    Boumard, Benjamin
    Bardin, Allison J.
    CURRENT OPINION IN CELL BIOLOGY, 2021, 73 : 58 - 68
  • [37] Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells
    Korzelius, Jerome
    Naumann, Svenja K.
    Loza-Coll, Mariano A.
    Chan, Jessica S. K.
    Dutta, Devanjali
    Oberheim, Jessica
    Glaesser, Christine
    Southall, Tony D.
    Brand, Andrea H.
    Jones, D. Leanne
    Edgar, Bruce A.
    EMBO JOURNAL, 2014, 33 (24) : 2967 - 2982
  • [38] Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in Drosophila
    Strilbytska, Olha M.
    Semaniuk, Uliana V.
    Storey, Kenneth B.
    Yurkevych, Ihor S.
    Lushchak, Oleh
    CELLS, 2020, 9 (04)
  • [39] Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells
    Hur, Jae H.
    Bahadorani, Sepehr
    Graniel, Jacqueline
    Koehler, Christopher L.
    Ulgherait, Matthew
    Rera, Michael
    Jones, D. Leanne
    Walker, David W.
    AGING-US, 2013, 5 (09): : 662 - 681
  • [40] The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila
    Li, Qi
    Li, Shuangxi
    Mana-Capelli, Sebastian
    Flach, Rachel J. Roth
    Danai, Laura V.
    Amcheslavsky, Alla
    Nie, Yingchao
    Kaneko, Satoshi
    Yao, Xiaohao
    Chen, Xiaochu
    Cotton, Jennifer L.
    Mao, Junhao
    McCollum, Dannel
    Jiang, Jin
    Czech, Michael P.
    Xu, Lan
    Ip, Y. Tony
    DEVELOPMENTAL CELL, 2014, 31 (03) : 291 - 304
12345