Immune modulation with extracorporeal photopheresis in renal transplantation: proof of concept clinical outcomes and perspective

被引：0
作者：
Crepin, Thomas [1 ,2 ]
Lionet, Arnaud [3 ]
Augusto, Jean-Francois [4 ]
Hazzan, Marc [3 ]
Garrouste, Cyril [5 ]
Heng, Anne-Elisabeth [5 ]
Ducloux, Didier [1 ,2 ]
机构：
[1] CHU Besancon, Serv Nephrol, Bd A Flemming, F-25000 Besancon, France
[2] UMR RIGHT 1098 Inserm EFS UFC, F-25000 Besancon, France
[3] CHU Lille, Serv Nephrol, Bd Prof Jules Leclercq, F-59000 Lille, France
[4] CHU Angers, Serv Nephrol, 4 Rue Larrey, F-49100 Angers, France
[5] CHU Clermont Ferrand, Serv Nephrol, 58 Rue Montalembert, F-63000 Clermont Ferrand, France
来源：
NEPHROLOGIE & THERAPEUTIQUE | 2023年 / 19卷 / 06期
关键词：
renal transplant; photopheresis; regulatory T cell; antibody-mediated rejection; VERSUS-HOST-DISEASE; BRONCHIOLITIS OBLITERANS SYNDROME; ANTIBODY-MEDIATED REJECTION; DONOR-SPECIFIC ANTIBODIES; STEROID-REFRACTORY ACUTE; REGULATORY T-CELLS; ALLOGRAFT REJECTION; CALCINEURIN INHIBITORS; DENDRITIC CELLS; PHOTOCHEMOTHERAPY;
D O I：
10.1684/ndt.2023.46
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
For 30 years, photopheresis is used to treat graft versus host disease and heart or lung allograft rejection. In this review, we discuss the place of photopheresis in kidney transplantation both in prevention or treatment of rejection. Mechanisms of action in kidney transplantation are mainly based on results observed in graft versus host disease and in heart or lung transplantation. Photopheresis may induce innate and adaptive immunity changes with restauration of a favourable Th1/Th2 immune balance, an expansion of LT /LB reg subsets, and a local enrichment in IL-10. French national clinical and mechanistic studies are underway to define the place of photopheresis therapy in immunomodulation strategies in kidney transplantation.
引用
收藏
页码：521 / 531
页数：11
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