Recent advances in senescence-associated secretory phenotype and osteoporosis

被引：4
作者：
Fan, Haonan [1 ]
Qiao, Zhi [1 ]
Li, Jitian [2 ]
Shang, Guowei [1 ]
Shang, Chunfeng [1 ]
Chen, Songfeng [1 ]
Leng, Zikuan [1 ]
Su, Huifang [1 ]
Kou, Hongwei [1 ]
Liu, Hongjian [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Orthoped, Zhengzhou 450000, Peoples R China
[2] Henan Luoyang Orthoped Hosp, Henan Prov Orthoped Hosp, Henan Inst Orthoped & Traumatol, Luoyang 471000, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 04期
关键词：
Cellular senescence; Osteoporosis; Senescence-associated secretory phenotype; (SASP); INHIBITING OXIDATIVE STRESS; DEFICIENCY-INDUCED OSTEOPOROSIS; CELLULAR SENESCENCE; KAPPA-B; BONE LOSS; DNA-DAMAGE; CELLS; EXPRESSION; C/EBP; DIFFERENTIATION;
D O I：
10.1016/j.heliyon.2024.e25538
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age. The senescenceassociated secretory phenotype (SASP), an essential cellular senescence hallmark, is an important mechanism connecting cellular senescence to osteoporosis. This review describes in detail the characteristics of SASPs and their regulatory agencies, and shed fresh light on how SASPs from different senescent cells contribute to osteoporosis development. Furthermore, we summarized various innovative therapy techniques that target SASPs to lower the burden of osteoporosis in the elderly and discussed the potential challenges of SASPs-based therapy for osteoporosis as a new clinical trial.
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页数：10
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