The dilated veins surrounding the cord in multiple sclerosis suggest elevated pressure and obstruction of the glymphatic system

被引：3
作者：
Bateman, Grant A. [1 ,2 ,4 ]
Bateman, Alexander R. [3 ]
机构：
[1] John Hunter Hosp, Dept Med Imaging, Newcastle, NSW, Australia
[2] Newcastle Univ, Fac Hlth, Callaghan Campus, Newcastle, NSW, Australia
[3] Univ New South Wales, Sch Mech Engn, Sydney, NSW, Australia
[4] John Hunter Hosp, Dept Med Imaging, Locked Bag 1,Newcastle Reg Mail Ctr, Newcastle 2310, Australia
来源：
NEUROIMAGE | 2024年 / 286卷
关键词：
Multiple sclerosis; Venous dilatation; Glymphatic; Impedance mismatch; SPINAL-CORD; SYRINGOMYELIA;
D O I：
10.1016/j.neuroimage.2024.120517
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recently, Clarke et al. published a study using spinal cord susceptibility weighted imaging in multiple sclerosis patients at 7T. They discovered dilated intradural extramedullary veins surrounding the cord. The purpose of this commentary is to point out some recent research by our group, which suggests this dilatation also occurs in the bridging cortical veins surrounding the brain. The dilatation indicates a focal elevation in the venous pressure secondary to impedance mismatching. Due to the shared outflow geometry, dilatation of the outflow veins will obstruct the glymphatic pathway of the spinal cord altering the immune response.
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页数：3
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