Copper-Catalyzed Radical Silylarylation of Activated Alkenes: Preparation of β-Silyl Amide-Pharmaceutical Hybrids

被引：7
作者：
Chen, Fei [1 ]
Liu, Shi-Yu [1 ]
Li, Xiao [1 ]
Jia, Jia-Lu [1 ]
Li, Yi [1 ]
Lu, Xiao-Lan [1 ]
Jia, Lin [1 ]
Zheng, Yang [1 ]
Yan, Zhongfei [1 ]
Li, Gang [1 ]
Lv, Yunhe [1 ]
Rong, Haojie [2 ]
机构：
[1] Anyang Normal Univ, Coll Chem & Chem Engn, Henan Prov Engn Technol Res Ctr Precise Synth Fluo, Henan Prov Key Lab New Optoelect Funct Mat, Anyang 455000, Peoples R China
[2] Xian Modern Chem Res Inst, State Key Lab Fluorine & Nitrogen Chem, Xian 710065, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 06期
基金：
中国国家自然科学基金;
关键词：
silylarylation; alkenes; copper-catalysis; beta-silyl amides; radical cascade reactions; late-stage modification of drug molecules; C-H SILYLATION; ELECTRON-DEFICIENT HETEROARENES; STEREOSELECTIVE-SYNTHESIS; FACILE ACCESS; MIGRATION/DESULFONYLATION; SILANES; ACIDS; DIFUNCTIONALIZATION; HYDROSILYLATION; VINYLSILANES;
D O I：
10.1002/adsc.202301434
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Copper-catalyzed silylarylation of N-(arylsulfonyl)acrylamides via a tandem silyl radical addition/1,4-aryl migration/desulfonylation sequence has been developed. This method employs silanes as the precursor of silyl radical and di-tert-butyl peroxide (DTBP) as the initiator. By using this cascade procedure, a series of beta-silyl amide-pharmaceutical hybrids which contain an alpha-all-carbon quaternary stereocenter were facilely synthesized.
引用
收藏
页码：1325 / 1330
页数：6
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