Fibroblast Insights into the Pathogenesis of Ankylosing Spondylitis

被引:10
作者
Liu, Zhenhua [1 ]
Cai, Mingxi [2 ]
Ke, Haoteng [2 ]
Deng, Huazong [2 ]
Ye, Weijia [2 ]
Wang, Tao [1 ]
Chen, Qifan [1 ]
Cen, Shuizhong [1 ]
机构
[1] Southern Med Univ, Zhujiang Hosp, Orthoped Med Ctr, Dept Spinal Surg, Guangzhou 510280, Peoples R China
[2] Southern Med Univ, Zhujiang Hosp, Clin Sch 2, Guangzhou 510280, Peoples R China
关键词
ankylosing spondylitis; fibroblast; inflammation; ossification; TUMOR-NECROSIS-FACTOR; INHIBITS OSTEOGENIC DIFFERENTIATION; LIGAMENT FIBROBLASTS; BONE-FORMATION; RADIOGRAPHIC PROGRESSION; SUBCHONDRAL BONE; DOWN-REGULATION; OSSIFICATION; INFLAMMATION; CELLS;
D O I
10.2147/JIR.S439604
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Purpose of the Review: Emerging evidence has shown that ankylosing spondylitis fibroblasts (ASFs) act as crucial participants in inflammation and abnormal ossification in ankylosing spondylitis (AS). This review examines the investigations into ASFs and their pathological behavior, which contributes to inflammatory microenvironments and abnormal bone formation. The review spans the period from 2000 to 2023, with a primary focus on the most recent decade. Additionally, the review provides an in-depth discussion on studies on ASF ossification at the cellular level. Recent Findings: ASFs organize immune functions by recruiting immune cells and influencing their differentiation and activation, thus mediate the inflammatory response in the early phase of disease. ASFs promote joint destruction at sites of cartilage and actively promote abnormal ossification by recruiting osteoblasts, differentiation into myofibroblasts or ossification directly. Many signaling pathways and cytokines such as Wnt signaling and BMP/TGF-beta signaling are involved in ASF ossification. Summary: ASFs play a key role in AS inflammation and osteogenesis. Further studies are required to elucidate molecular mechanisms behind that and provide new targets and directions for AS diagnosis and treatment from a new perspective of fibroblasts.
引用
收藏
页码:6301 / 6317
页数:17
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