Multi-omics for COVID-19: driving development of therapeutics and vaccines

被引：9
|
作者：
Guo, Mengyu [1 ,2 ]
Xiong, Muya [3 ,17 ]
Peng, Jinying [5 ]
Guan, Tong [1 ,2 ,17 ]
Su, Haixia [3 ,17 ]
Huang, Yanyi [4 ,9 ,15 ,16 ]
Yang, Cai-Guang [6 ,17 ]
Li, Yang [7 ,8 ]
Boraschi, Diana [7 ,8 ,12 ]
Pillaiyar, Thanigaimalai [13 ,14 ]
Wang, Guanbo [4 ,9 ]
Yi, Chengqi [5 ,10 ,11 ,15 ]
Xu, Yechun [3 ,17 ]
Chen, Chunying [1 ,2 ,17 ,18 ]
机构：
[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[2] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[4] Peking Univ, Biomed Pioneering Innovat Ctr, Beijing 100871, Peoples R China
[5] Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China
[6] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Chem Biol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[7] Chinese Acad Sci, Shenzhen Inst Adv Technol, Lab Immunol & Nanomed, Shenzhen 518055, Peoples R China
[8] Chinese Acad Sci, Shenzhen Inst Adv Technol, China Italy Joint Lab Pharmacobiotechnol Med Immun, Shenzhen 518055, Peoples R China
[9] Shenzhen Bay Lab, Inst Cell Anal, Shenzhen 528107, Peoples R China
[10] Peking Univ, Coll Chem & Mol Engn, Dept Chem Biol, Beijing 100871, Peoples R China
[11] Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China
[12] CNR, Inst Biochem & Cell Biol, I-80131 Naples, Italy
[13] Eberhard Karls Univ Tubingen, Inst Pharm, Pharmaceut Med Chem, D-72076 Tubingen, Germany
[14] Eberhard Karls Univ Tubingen, Tuebingen Ctr Acad Drug Discovery, D-72076 Tubingen, Germany
[15] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
[16] Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing, Peoples R China
[17] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[18] GBA Natl Inst Nanotechnol Innovat, Guangzhou 510700, Peoples R China
来源：
NATIONAL SCIENCE REVIEW | 2023年 / 10卷 / 09期
基金：
中国国家自然科学基金;
关键词：
COVID-19; SARS-CoV-2; multi-omics; antibodies; small-molecule drugs; vaccines; POTENT NEUTRALIZING ANTIBODIES; SARS-COV-2; INFECTION; TRAINED IMMUNITY; MUTATIONS; RESPONSES; EFFICACY; ESCAPE; IMMUNOGENICITY; ESTABLISHMENT; VACCINATION;
D O I：
10.1093/nsr/nwad161
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and economy. The development of therapeutics and vaccines to combat this virus is continuously progressing. Multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, epigenomics and metallomics, have helped understand the structural and molecular features of the virus, thereby assisting in the design of potential therapeutics and accelerating vaccine development for COVID-19. Here, we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19, in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines. Understanding the roles of multi-omics in COVID-19 facilitates the development of novel therapeutics and provides guidance for the rational design of vaccines.
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页数：30
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