Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: A review

被引：49

作者：

Liu, Yubin ^{[1
,2
]}

Lu, Lan ^{[3
]}

Yang, Huan ^{[1
,2
]}

Wu, Xu ^{[1
,2
,4
]}

Luo, Xinyue ^{[1
]}

Shen, Jing ^{[1
,2
,4
]}

Xiao, Zhangang ^{[1
,2
,4
]}

Zhao, Yueshui ^{[1
,2
,4
]}

Du, Fukuan ^{[1
,2
,4
]}

Chen, Yu ^{[1
,2
,4
]}

Deng, Shuai ^{[1
,2
,4
]}

Cho, Chi Hin ^{[1
,2
]}

Li, Qianxiu ^{[1
,2
]}

Li, Xiaobing ^{[1
]}

Li, Wanping ^{[1
]}

Wang, Fang ^{[1
]}

Sun, Yuhong ^{[1
]}

Gu, Li ^{[1
]}

Chen, Meijuan ^{[1
]}

Li, Mingxing ^{[1
,2
,4
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China

[2] Cell Therapy & Cell Drugs Luzhou Key Lab, Luzhou, Sichuan, Peoples R China

[3] Chengdu Univ, Sichuan Ind Inst Antibiot, Sch Pharm, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China

[4] South Sichuan Inst Translat Med, Luzhou, Sichuan, Peoples R China

来源：

ENVIRONMENTAL POLLUTION | 2023年 / 339卷

关键词：

Cigarette smoking; Immune system; Inflammation; Carcinogenesis; DNA damage; Epigenetic modification; POLYCYCLIC AROMATIC-HYDROCARBONS; NF-KAPPA-B; HUMAN LUNG FIBROBLASTS; REGULATORY T-CELLS; TNF-ALPHA; BLADDER-CANCER; PULMONARY INFLAMMATION; OXIDATIVE STRESS; CADMIUM EXPOSURE; TOBACCO SMOKING;

D O I：

10.1016/j.envpol.2023.122730

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Smoking is a serious global health issue. Cigarette smoking contains over 7000 different chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons and heavy metals, which play the key role for cigarette-induced inflammation and carcinogenesis. Growing evidences show that cigarette smoking and its components exert a remarkable impact on regulation of immunity and dysregulated immunity promotes inflammation and cancer. Therefore, this comprehensive and up-to-date review covers four interrelated topics, including cigarette smoking, inflammation, cancer and immune system. The known harmful chemicals from cigarette smoking were summarized. Importantly, we discussed in depth the impact of cigarette smoking on the formation of inflammatory or tumor microenvironment, primarily by affecting immune effector cells, such as macrophages, neutrophils, and T lymphocytes. Furthermore, the main molecular mechanisms by which cigarette smoking induces inflammation and cancer, including changes in epigenetics, DNA damage and others were further summarized. This article will contribute to a better understanding of the impact of cigarette smoking on inducing inflammation and cancer.

引用

页数：17

共 229 条

[1] Benzo[a]pyrene immunogenetics and immune archetype reprogramming of lung [J].