The Management of Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With Biologics

被引：19

作者：

Wautlet, A. ^{[1
]}

Bachert, C. ^{[2
,3
,4
]}

Desrosiers, M. ^{[5
]}

Hellings, Peter W. ^{[6
,7
]}

Peters, Anju T. ^{[1
,8
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Allergy Immunol, Chicago, IL 60610 USA

[2] Univ Hosp Munster, Dept Otorhinolaryngol Head & Neck Surg, Munster, Germany

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Int Airway Res Ctr, Dept Otorhinolaryngol, Guangzhou, Peoples R China

[4] Univ Ghent, Fac Med, Dept Otorhinolaryngol, Upper Airways Res Lab, Ghent, Belgium

[5] Ctr Hosp Univ Montreal CRCHUM, Ctr Rech, Montreal, PQ, Canada

[6] Univ Hosp Leuven, Dept Otorhinolaryngol, Leuven, Belgium

[7] Univ Ghent, Fac Med, Upper Airways Res Lab, Ghent, Belgium

[8] Northwestern Univ, Feinberg Sch Med, Div Allergy & Immunol, Chicago, IL 60610 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2023年 / 11卷 / 09期

关键词：

Chronic rhinosinusitis; Nasal polyps; Biologics; RISK-FACTORS; PREVALENCE; OMALIZUMAB; ASTHMA; INFLAMMATION; GENETICS; EFFICACY; SAFETY; STATE;

D O I：

10.1016/j.jaip.2023.04.054

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Chronic rhinosinusitis with nasal polyps affects a significant portion of the worldwide population. This illness is associated with several chronic conditions and has an important impact on patient quality of life, leading to a great societal economic burden. In recent years, biologic medications have been developed and found to be effective in the treatment of chronic rhinosinusitis with nasal polyps. This review focuses on these treatment options and their ability to improve patient outcomes, including quality of life. It also reviews available evidence with regards to patient selection, monitoring of patients after treatment initiation, and comparison of different biologics and with other treatment options such as sinus surgery. & COPY; 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:2642-51)

引用

页码：2642 / 2651

页数：10

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