Clinical investigation of botulinum toxin (prabotulinumtoxin A) for bruxism related to masseter muscle hypertrophy: A prospective study

被引：5

作者：

Jung, Bok Ki ^{[1
]}

Park, Hojin ^{[2
]}

Cheon, Young Woo ^{[3
]}

Yun, In Sik ^{[1
]}

Choi, Jong-Woo ^{[4
,9
]}

Kim, Han Jo ^{[5
]}

Lee, Mu Young ^{[6
]}

Kang, Byeong Su ^{[7
]}

Kang, Tae Jo ^{[8
]}

机构：

[1] Univ Yonsei, Gangnam Severance Hosp, Dept Plast & Reconstruct Surg, Coll Med, 211 Eonjuro, Seoul 06273, South Korea

[2] Korea Univ, Anam Hosp, Coll Med, Seoul, South Korea

[3] Gachon Univ, Coll Med, Gil Med Ctr, Dept Plast & Reconstruct Surg, Incheon, South Korea

[4] Univ Ulsan, Asan Med Ctr, Coll Med, Seoul, South Korea

[5] Eight Plast Surg, Seoul, South Korea

[6] SM Plast Surg, Seoul, South Korea

[7] Woori Plast Surg Clin, Seoul, South Korea

[8] Yujin Esthet Surg Clin, Seoul, South Korea

[9] Univ Ulsan, Asan Med Ctr, Dept Plast Surg, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea

来源：

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | 2023年 / 51卷 / 05期

关键词：

Botulinum toxins; Bruxism; Masseter muscle; DOUBLE-BLIND; EFFICACY; MODERATE; SAFETY; PAIN;

D O I：

10.1016/j.jcms.2023.05.005

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

This study aims to confirm the effectiveness and safety of a prabotulinumtoxin type A (praBTX-A) injection in patients with bruxism and masseter hypertrophy. The study included patients who ground or clenched their teeth while sleeping and had computed tomography (CT) scans that showed a maximum thickness of the masseter muscle of 15 mm or more. The praBTX-A was administered bilaterally into the masseter muscles; 15 U/side for group 1, 25 U/side for group 2, and 35 U/side for group 3. CT scans and bruxism questionnaires were conducted before and eight weeks after the injection. Thirty-seven patients were enrolled, but three dropped out due to loss of follow-up. After injection, masseter thickness decreased to 15.1 & PLUSMN; 2.0 mm for group 1, 14.3 & PLUSMN; 2.9 mm for group 2, and 13.4 & PLUSMN; 1.8 mm for group 3 (p = 0.043). Group 3 showed a statistically significant lower masseter thickness compared to group 1 (p = 0.039). Both subjective and objective frequencies of bruxism decreased for all groups, but there were no significant differences in either subjective (p = 0.396) or objective frequencies (p = 0.87) between the groups after the injection. The results of this study suggest that praBTX-A injection is a safe and effective treatment for bruxism and masseter hypertrophy. A dosage of 35 IU/side can effectively decrease masseter thickness and relieve bruxism symptoms. Even the minimum dosage of 15 IU/side can contribute to improvements in bruxism symptoms. This investigation provides valuable information for managing bruxism that is associated with hypertrophic masseter muscles. & COPY; 2023 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

引用

页码：332 / 337

页数：6