The Association between ACTN3 R577X Polymorphism and Range of Motion: A Systematic Review and Meta-analysis

被引:1
作者
Saito, Mika [1 ,3 ]
Zempo, Hirofumi [2 ]
de Almeida, Kathleen Yasmin [1 ]
Homma, Hiroki [1 ]
Kikuchi, Naoki [1 ]
机构
[1] Nippon Sport Sci University, Grad Sch Hlth & Sport Sci, Tokyo, Japan
[2] Tokyo Seiei Coll, Fac Hlth & Nutr, Katsushika, Japan
[3] Nippon Sport Sci Univ, Grad Sch Hlth & Sport Sci, Yokohama, Tokyo, Japan
关键词
ACTN3; & alpha; -actinin-3; genotype; flexibility; ROM; PASSIVE MUSCLE-STIFFNESS; TRUNK FLEXIBILITY; ALPHA-ACTININ-3; GENOTYPE; STRENGTH; PERFORMANCE; DEFICIENCY; ENDURANCE; DAMAGE; FORCE;
D O I
10.1055/a-2035-8300
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
The R577X polymorphism in the a-actinin-3 gene ( ACTN3 ) is associated with muscle strength and power; there is an association between ACTN3 R577X polymorphism and range of motion (ROM). We examined the effect of the ACTN3 R577X polymorphism on ROM through meta-analysis and systematic review. Relevant studies published before April 14, 2022 were identified from the PubMed database using the following keywords and Boolean operators: ("flexibility" or "Joint Range of Motion" or "Joint Flexibility" or "Range of motion") and ("ACTN3" or "alpha-actinin 3"). Studies that met the following criteria were included: (1) published in English, (2) included human subjects, (3) provided ROM measurements, and (4) analyzed the ACTN3 R577X genotype. A total of 2908 participants from seven studies were included in the meta-analysis. The additive genetic model was assessed using a meta-regression model, and dominant and recessive models were analyzed using a random effects model. The ROM in the XX+RX genotype was significantly higher than that in the RR genotype (recessive model: p<0.001), and it increased additively in the order XX>RX>RR (additive model: p=0.029). However, no significant association was observed in the dominant model. These findings further elucidate the association between flexibility and the ACTN3 R577X genotype.
引用
收藏
页码:618 / 624
页数:7
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