Impact of Denture Use on Ischemic and Bleeding Outcomes of Patients with Acute Myocardial Infarction

Objective Oral diseases, including periodontitis and stomatitis, are highly prevalent worldwide and report-edly associated with the development of cardiovascular disease. Given the high rate of stomatitis in individu-als wearing dentures, denture users may be at high risk of poor cardiovascular outcomes. We therefore inves-tigated whether or not the use of dentures is associated with a poor clinical outcome in patients with acute myocardial infarction (MI). Methods This two-center retrospective observational study was conducted between January 2012 and March 2020. A total of 1,046 patients with acute MI who underwent primary percutaneous coronary interven-tion were divided into two groups according to denture use status. The primary outcomes included ischemic events (cardiovascular death, recurrent MI, and ischemic stroke) and major bleeding (Bleeding Academic Re-search Consortium type 3 or 5). Results Of the 1,046 patients with acute MI, 387 (37.0%) used dentures. An older age and prior MI were associated with an increased likelihood of denture use. During the mean 660-day follow-up period, ischemic and major bleeding events occurred in 169 (16.2%) and 102 (9.8%) patients, respectively. Denture use was associated with an increased risk of ischemic events, whereas no significant intergroup differences were ob-served in major bleeding outcomes. The results were similar among patients >= 75 years old. Conclusion More than one-third of the patients with acute MI wore dentures. Our findings suggest that denture use is significantly associated with an increased risk of ischemic events but not bleeding outcomes after acute MI.