Gut Microbiota and Atrial Fibrillation: Pathogenesis, Mechanisms and Therapies

被引：4

作者：

Al-Kaisey, Ahmed M. ^{[1
,2
]}

Figgett, William ^{[3
]}

Hawson, Joshua ^{[1
,2
]}

Mackay, Fabienne ^{[4
]}

Joseph, Stephen A. ^{[1
,5
]}

Kalman, Jonathan M. ^{[1
,2
]}

机构：

[1] Royal Melbourne Hosp, Dept Cardiol, Melbourne, Australia

[2] Univ Melbourne, Dept Med, Melbourne, Australia

[3] Garvan Inst Med Res, Darlinghurst, NSW, Australia

[4] QIMR Berghofer Med Res Inst, Herston, Qld, Australia

[5] Western Hlth, Dept Cardiol, Melbourne, Australia

来源：

ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW | 2023年 / 12卷

基金：

英国医学研究理事会;

关键词：

Atrial fibrillation; gut microbiota; microbiome; inflammation; catheter ablation; TRIMETHYLAMINE-N-OXIDE; ACIDS INDUCE ARRHYTHMIAS; INTESTINAL MICROBIOTA; NLRP3; INFLAMMASOME; INDOXYL SULFATE; HEART-FAILURE; UREMIC TOXIN; METABOLITE; IDENTIFICATION; EPIDEMIOLOGY;

D O I：

10.15420/aer.2022.33

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the past decade there has been an interest in understanding the role of gut microbiota in the pathogenesis of AF. A number of studies have linked the gut microbiota to the occurrence of traditional AF risk factors such as hypertension and obesity. However, it remains unclear whether gut dysbiosis has a direct effect on arrhythmogenesis in AF. This article describes the current understanding of the effect of gut dysbiosis and associated metabolites on AF. In addition, current therapeutic strategies and future directions are discussed.

引用

页数：6

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