Tumor treating fields: a new treatment for glioblastoma

被引：3
|
作者：
Slavkov, Dimitar [1 ,4 ]
Hadzhiyanev, Asen [2 ]
Slavkova, Svetoslava [3 ]
机构：
[1] HELIOS Vogtland Klinikum Plauen GmbH, Clin Neurosurg Spine Surg & Neuromodulat, Plauen, Germany
[2] Med Univ Sofia, Univ Hosp St Ivan Rilsky, Dept Neurosurg, Sofia, Bulgaria
[3] HELIOS Vogtland Klinikum Plauen GmbH, Clin Dermatol, Plauen, Germany
[4] HELIOS Vogtland Klinikum Plauen GmbH, Clin Neurosurg Spine Surg & Neuromodulat, Rontgenstr 2, D-08253 Plauen, Germany
来源：
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | 2023年 / 37卷 / 01期
关键词：
glioblastoma; therapy; tumor treating fields; TTF; TEMOZOLOMIDE;
D O I：
10.1080/13102818.2022.2155567
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Glioblastoma (GBM) is a fatal type of brain tumour. According to the World Health Organization (WHO) classification of 2021, GBMs have WHO grade 4 and are usually associated with a poor prognosis. Since GBMs show a pronounced infiltrative growth, a cure by complete resection of the tumor is unfortunately not possible. Both systemic and locoregional therapy methods are traditionally used and tested to improve the prognosis. A new method that is intended to prolong the progression-free survival is using electromagnetic alternating fields, the so-called tumor treating fields (TTF). This method is based on alternating electrical fields that act on the shaved scalp. The aim is to disrupt cell division and organization of cell organelles. In this review, we discuss the mechanism of TTF, summarize the results of our comprehensive literature search, and discuss potential of this new anti-cancer treatment modality.
引用
收藏
页码：58 / 63
页数：6
相关论文
共 50 条
  • [21] Tumor Treating Fields for Glioblastoma Treatment: Patient Satisfaction and Compliance With the Second-Generation Optune® System
    Kinzel, Adrian
    Ambrogi, Michael
    Varshaver, Michael
    Kirson, Eilon D.
    CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2019, 13
  • [22] What is the Role of Tumor-treating Fields in Newly Diagnosed Glioblastoma?
    Ornelas, Abbie S.
    Porter, Alyx B.
    Sharma, Akanksha
    Knox, Molly G.
    Marks, Lisa A.
    Wingerchuk, Dean M.
    O'Carroll, Cumara B.
    NEUROLOGIST, 2019, 24 (02) : 71 - 73
  • [23] Tumor treating fields in glioblastoma: long-term treatment and high compliance as favorable prognostic factors
    Wang, Junjie
    Du, Quan
    Chen, Jiarui
    Liu, Jianjian
    Gu, Zhaowen
    Wang, Xiaoyu
    Zhang, Anke
    Gao, Shiqi
    Shao, Anwen
    Zhang, Jianmin
    Wang, Yongjie
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [24] The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
    Riley, Mercedes M.
    San, Pyay
    Lok, Edwin
    Swanson, Kenneth D.
    Wong, Eric T.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2019, (146):
  • [25] Rationale and Background on Tumor-Treating Fields for Glioblastoma
    Schwartz, Margaret A.
    Onuselogu, Lynnette
    CLINICAL JOURNAL OF ONCOLOGY NURSING, 2016, 20 (05) : 20 - 24
  • [26] Tumor-Treating Fields for the treatment of glioblastoma: a systematic review and meta-analysis
    Regev, Ohad
    Merkin, Vladimir
    Blumenthal, Deborah T.
    Melamed, Israel
    Kaisman-Elbaz, Tehila
    NEURO-ONCOLOGY PRACTICE, 2021, 8 (04) : 426 - 440
  • [27] Tumor Treating Fields Alter the Kinomic Landscape in Glioblastoma Revealing Therapeutic Vulnerabilities
    Jones, Amber B.
    Schanel, Taylor L.
    Rigsby, Mikayla R.
    Griguer, Corinne E.
    Mcfarland, Braden C.
    Anderson, Joshua C.
    Willey, Christopher D.
    Hjelmeland, Anita B.
    CELLS, 2023, 12 (17)
  • [28] Clinical Efficacy of Tumor Treating Fields for Newly Diagnosed Glioblastoma
    Liu, Yang
    Strawderman, Myla S.
    Warren, Kwanza T.
    Richardson, Margie
    Serventi, Jennifer N.
    Mohile, Nimish A.
    Milano, Michael T.
    Walter, Kevin A.
    ANTICANCER RESEARCH, 2020, 40 (10) : 5801 - 5806
  • [29] Recent advances in Tumor Treating Fields (TTFields) therapy for glioblastoma
    Khagi, Simon
    Kotecha, Rupesh
    Gatson, Na Tosha N.
    Jeyapalan, Suriya
    Abdullah, Huda Ismail
    Avgeropoulos, Nicholas G.
    Batzianouli, Eleni T.
    Giladi, Moshe
    Lustgarten, Leonardo
    Goldlust, Samuel A.
    ONCOLOGIST, 2024,
  • [30] Tumor treating fields in the management of Glioblastoma: opportunities for advanced imaging
    Soni, Vikram S.
    Yanagihara, Ted K.
    CANCER IMAGING, 2019, 19 (01)
12345