Margin to depth of invasion ratio as an indicator for stratifying close margins in early-stage oral squamous cell carcinoma

被引:4
|
作者
Hung, Chun -Yang [1 ]
Lee, Tung -Lin [1 ]
Chang, Chun -Wei [1 ]
Wang, Cheng-Ping [1 ]
Lin, Mei -Chun [1 ]
Lou, Pei -Jen [1 ]
Chen, Tseng-Cheng [1 ,2 ]
机构
[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Otolaryngol, Taipei, Taiwan
[2] Mail Address 7,Chung Shan S Rd, Taipei 10002, Taiwan
关键词
Oral squamous cell carcinoma; Early stage; Close margin; Depth of invasion; Margin -to -depth -of -invasion ratio; Disease -free survival; Overall survival; Local recurrence; RECURRENCE; SURVIVAL; IMPACT; RISK;
D O I
10.1016/j.oraloncology.2024.106726
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
<bold>Objectives: </bold>In early-stage oral squamous cell carcinoma (OSCC) patients, whether the margin-to-depth-of-invasion ratio (MDR) can assist in stratifying the prognosis remains unclear. <bold>Methods: </bold>Patients diagnosed with early stage OSCC at National Taiwan University Hospital between January 2007 and December 2021 were reviewed. Patients with margin > 1 mm were classified into two groups: MDR < 0.5 and MDR >= 0.5. <bold>Results: </bold>We analyzed 911 pT1-2N0M0 OSCC patients, 723 (79.36 %) with MDR >= 0.5 and 188 (20.64 %) with MDR < 0.5. Patients in the MDR < 0.5 group displayed a significantly higher local recurrence rate (odds ratio 2.81, p = 0.002) compared with MDR >= 0.5 group. The 5-year disease-free survival were 80.8 % for clear margin, 76.3 % for close margin (MDR >= 0.5), and 65.2 % for close margin (MDR < 0.5). The overall survival displayed a similar pattern, with 5-year rates of 88.3 % for clear margin, 86.8 % for close margin (MDR >= 0.5), and 75.0 % for close margin (MDR < 0.5). There were no significant overall survival differences between the two MDR >= 0.5 groups, but both were significantly superior to patients with MDR < 0.5 (p = 0.001; p = 0.01). After multivariant cox analysis, MDR < 0.5 was a significant risk factor for disease-free survival (p < 0.001). <bold>Conclusion: </bold>For early stage OSCC patients without positive margin (<= 1mm), the survival outcome between MDR >= 0.5 group and MDR < 0.5 group was significantly different. The MDR < 0.5 group had significantly higher risk of local recurrence that may warrant adjuvant treatment.
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页数:8
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