Pregnancy effect on disease activity in women with multiple sclerosis treated with cladribine

被引：2

作者：

Signoriello, E. ^{[1
]}

Foschi, M. ^{[2
,3
]}

Lanzillo, R. ^{[4
]}

Frau, J. ^{[5
]}

Cocco, E. ^{[5
]}

Borriello, G. ^{[6
]}

Ianniello, A. ^{[7
]}

Trotta, M. ^{[8
]}

Landi, D. ^{[9
]}

Maniscalco, G. T. ^{[10
,11
]}

Ruscica, F. ^{[12
,13
]}

Toscano, S. ^{[14
]}

Patti, F. ^{[14
]}

Zanghi, A. ^{[15
]}

D'Amico, E. ^{[15
]}

Fantozzi, R. ^{[16
]}

Centonze, D. ^{[16
]}

Lus, G. ^{[1
]}

Bonavita, S. ^{[1
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Multiple Sclerosis Ctr, Dept Adv Med & Surg Sci, Div Neurol 2, Naples, Italy

[2] S Maria Croci Hosp, Dept Neurosci, Neurol Unit, AUSL Romagna,MS Ctr, Ravenna, Italy

[3] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy

[4] Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Naples, Italy

[5] Univ Cagliari, Binaghi Hosp, Multiple Sclerosis Ctr, Dept Med Sci & Publ Hlth, Cagliari, Italy

[6] San Pietro Fatebenefratelli Hosp, MS Ctr Rome, Rome, Italy

[7] Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy

[8] AO Annunziata, Unit Neurol, Cosenza, Italy

[9] Univ Roma Tor Vergata, Tor Vergata Univ Hosp, Dept Syst Med, Multiple Sclerosis Clin & Res Unit, Rome, Italy

[10] A Cardarelli Hosp, Neurol Clin, Naples, Italy

[11] A Cardarelli Hosp, Multiple Sclerosis Ctr, Naples, Italy

[12] UOC Neurol, Cefalu, PA, Italy

[13] Ctr SMFdn Ist G Giglio, Cefalu, PA, Italy

[14] Univ Catania, Dept GF Ingrassia, Sect Neurosci, Catania, Italy

[15] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy

[16] IRCCS Neuromed, Unit Neurol, Pozzilli, IS, Italy

来源：

JOURNAL OF NEUROLOGY | 2024年 / 271卷 / 07期

关键词：

Cladribine; Multiple sclerosis; Pregnancy; Breastfeeding; Disease activity;

D O I：

10.1007/s00415-024-12291-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Cladribine is an oral immune reconstitution therapy for relapsing multiple sclerosis (RMS). Hormonal and immune changes are responsible for the decline of disease activity in the third trimester of pregnancy and disease reactivation in the early post-partum period.We investigate the impact of pregnancy on disease activity in women with MS who conceived after cladribine treatment.Methods We recruited women of childbearing age with relapsing-remitting MS (RRMS) who became pregnant or not after being treated with cladribine. For both groups, demographic, clinical and radiological data were collected 1 year before and after treatment during a mean follow-up of 3.53 years. We compared disease activity over time between groups using variance analysis for repeated measures.Results 48 childbearing women were included. 25 women had a pregnancy after a mean of 1.75 years from the first treatment cycle. Women with or without pregnancy did not differ in demographics or pre-cladribine disease activity. No significant differences in disease activity or EDSS worsening were found between women with or without pregnancy.Discussion Our findings suggest that pregnancy does not appear to influence disease activity and disability in women previously treated with cladribine; further studies with larger numbers and longer follow-up are needed to confirm this finding.

引用

页码：4039 / 4045

页数：7

共 16 条

[1] Fertility, Pregnancy and Childbirth in Patients with Multiple Sclerosis: Impact of Disease-Modifying Drugs [J].