Association between Gout and Gastric Cancer: A Nested Case-Control Study Using a National Health Sample Cohort

被引：1

作者：

Kwon, Mi Jung ^{[1
]}

Han, Kyeong Min ^{[2
]}

Kim, Ji Hee ^{[3
]}

Kim, Joo-Hee ^{[4
]}

Kim, Min-Jeong ^{[5
]}

Kim, Nan Young ^{[6
]}

Choi, Hyo Geun ^{[7
]}

Kang, Ho Suk ^{[8
]}

机构：

[1] Hallym Univ, Sacred Heart Hosp, Coll Med, Dept Pathol, Anyang 14068, South Korea

[2] Hallym Univ, Coll Med, Hallym Data Sci Lab, Anyang 14068, South Korea

[3] Hallym Univ, Sacred Heart Hosp, Coll Med, Dept Neurosurg, Anyang 14068, South Korea

[4] Hallym Univ, Sacred Heart Hosp, Dept Med, Div Pulm Allergy & Crit Care Med,Coll Med, Anyang 14068, South Korea

[5] Hallym Univ, Sacred Heart Hosp, Coll Med, Dept Radiol, Anyang 14068, South Korea

[6] Hallym Univ, Hallym Inst Translat Genom & Bioinformat, Med Ctr, Anyang 14068, South Korea

[7] Suseo Seoul ENT Clin & MD Analyt, Seoul 06349, South Korea

[8] Hallym Univ, Sacred Heart Hosp, Coll Med, Dept Internal Med, Anyang 14068, South Korea

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2024年 / 14卷 / 03期

关键词：

gastric cancer; gout; national healthcare data; nested case-control study; INCREASED RISK; COLCHICINE; SCORE;

D O I：

10.3390/jpm14030229

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Given the global significance of gout and gastric cancer (GC) as major health problems with interrelated impacts, we examined the development of GC in Korean patients with gout. We conducted a nested case-control study using data from 10,174 GC patients and 40,696 control patients from the Korean National Health Insurance Service-National Sample Cohort database. Propensity score matching (1:4) with propensity score overlap-weighted adjustment was used to reduce selection bias and estimate the odds ratio (OR) and 95% confidence intervals (CIs) for the association between gout and GC. An adjusted OR for GC was not significantly higher in patients with gout than in control patients (1.02; 95% CI, 0.93-1.12; p = 0.652). Additionally, no association between gout and GC was observed in subgroup analyses such as sex, age, level of income, region of residence, or Charlson Comorbidity Index score. In conclusion, these results suggest that gout is not a significant independent risk factor for GC among the Korean population. Additional investigation is required to establish a causal association between gout and GC, and to generalize these results to general populations.

引用

页数：10

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