Exploring the Antimicrobial, Antioxidant, and Antiviral Potential of Eco-Friendly Synthesized Silver Nanoparticles Using Leaf Aqueous Extract of Portulaca oleracea L.

被引：10

作者：

Abdel-Rahman, Mohammed Ali ^{[1
]}

Alshallash, Khalid S. ^{[2
]}

Eid, Ahmed M. ^{[1
]}

Hassan, Saad El-Din ^{[1
]}

Salih, Mutaz ^{[3
]}

Hamza, Mohammed F. ^{[4
,5
]}

Fouda, Amr ^{[1
]}

机构：

[1] Al Azhar Univ, Fac Sci, Bot & Microbiol Dept, Cairo 11884, Egypt

[2] Imam Mohammad Ibn Saud Islamic Univ IMSIU, Coll Sci, Dept Biol, Riyadh 11623, Saudi Arabia

[3] Imam Mohammad Ibn Saud Islamic Univ IMSIU, Coll Sci, Dept Chem, Riyadh 11623, Saudi Arabia

[4] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China

[5] Nucl Mat Author, POB 530, Cairo 11728, Egypt

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 03期

关键词：

green synthesis; Portulaca oleracea; silver nanoparticles; biomedical applications; antimicrobial; antiviral activity; GREEN SYNTHESIS; ANTIBACTERIAL; SIZE;

D O I：

10.3390/ph17030317

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein, the prospective applications of green fabricated silver nanoparticles (Ag-NPs) within the biomedical field were investigated. The leaf aqueous extract of Portulaca oleracea L., a safe, cheap, and green method, was used to fabricate Ag-NPs. The maximum plasmon resonance of synthesized NPs has appeared at 420 nm. The various biomolecules present in the plant extract to assemble spherical Ag-NPs with sizes of 5-40 nm were analyzed using Fourier transform infrared and transmission electron microscopy. The Ag was the major content of the formed Ag-NPs with an atomic percent of 54.95% and weight percent of 65.86%, as indicated by EDX. The crystallographic structure of synthesized NPs was confirmed by the diffraction of the X-ray. The dynamic light scattering exhibits the homogeneity and mono-dispersity nature with a polydispersity index of 0.37 in the colloidal fluid and a zeta potential value of -36 mV. The synthesized Ag-NPs exhibited promising antimicrobial efficacy toward various prokaryotic and eukaryotic pathogenic microorganisms with low MIC values of 12.5 mu g mL(-1) and 6.25 mu g mL(-1), respectively. Additionally, the P. oleracea-formed Ag-NPs showed optimistic antioxidant activity assessed by DPPH and H2O2 assay methods with the highest scavenging percentages of 88.5 +/- 2.3% and 76.5 +/- 1.7%, respectively, at a concentration of 200 mu g mL(-1). Finally, the biosynthesized Ag-NPs showed high antiviral properties toward the hepatitis A virus and Cox-B4 with inhibition percentages of 79.16 +/- 0.5% and 73.59 +/- 0.8%, respectively. Overall, additional research is essential to explore the Ag-NP-based aqueous extract of P. oleracea for human health. In the current investigation the use of synthesized Ag-NPs as antimicrobial, antioxidant, and antiviral agents to protect against pathogenic microbes, degenerative diseases caused by various oxidative stresses, and deadly viruses is recommended.

引用

页数：19