Cancer stem cell-immune cell crosstalk in breast tumor microenvironment: a determinant of therapeutic facet

被引：4
作者：
Guha, Aishwarya [1 ]
Goswami, Kuntal Kanti [2 ]
Sultana, Jasmine [1 ]
Ganguly, Nilanjan [1 ]
Choudhury, Pritha Roy [1 ]
Chakravarti, Mohona [1 ]
Bhuniya, Avishek [1 ]
Sarkar, Anirban [1 ]
Bera, Saurav [1 ]
Dhar, Sukanya [1 ]
Das, Juhina [1 ]
Das, Tapasi [1 ]
Baral, Rathindranath [1 ]
Bose, Anamika [3 ]
Banerjee, Saptak [1 ]
机构：
[1] Chittaranjan Natl Canc Inst, Dept Immunoregulat & Immunodiagnost, Kolkata, India
[2] Asutosh Coll, Dept Microbiol, Kolkata 700026, India
[3] Natl Inst Pharmaceut Educ & Res NIPER Sahibzada Aj, Dept Pharmaceut Technol Biotechnol, Mohali, Punjab, India
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
breast cancer (BC); breast cancer stem cells (BCSCs); tumor microenvironment (TME); innate immune cells; adaptive immune cells; DENDRITIC CELLS; MESENCHYMAL TRANSITION; SYSTEMIC THERAPY; TARGETED THERAPY; POOR-PROGNOSIS; T-CELLS; EXPRESSION; PROMOTE; METASTASIS; GROWTH;
D O I：
10.3389/fimmu.2023.1245421
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Breast cancer (BC) is globally one of the leading killers among women. Within a breast tumor, a minor population of transformed cells accountable for drug resistance, survival, and metastasis is known as breast cancer stem cells (BCSCs). Several experimental lines of evidence have indicated that BCSCs influence the functionality of immune cells. They evade immune surveillance by altering the characteristics of immune cells and modulate the tumor landscape to an immune-suppressive type. They are proficient in switching from a quiescent phase (slowly cycling) to an actively proliferating phenotype with a high degree of plasticity. This review confers the relevance and impact of crosstalk between immune cells and BCSCs as a fate determinant for BC prognosis. It also focuses on current strategies for targeting these aberrant BCSCs that could open avenues for the treatment of breast carcinoma.
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页数：18
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