Cancer stem cell-immune cell crosstalk in breast tumor microenvironment: a determinant of therapeutic facet

被引：4

作者：

Guha, Aishwarya ^{[1
]}

Goswami, Kuntal Kanti ^{[2
]}

Sultana, Jasmine ^{[1
]}

Ganguly, Nilanjan ^{[1
]}

Choudhury, Pritha Roy ^{[1
]}

Chakravarti, Mohona ^{[1
]}

Bhuniya, Avishek ^{[1
]}

Sarkar, Anirban ^{[1
]}

Bera, Saurav ^{[1
]}

Dhar, Sukanya ^{[1
]}

Das, Juhina ^{[1
]}

Das, Tapasi ^{[1
]}

Baral, Rathindranath ^{[1
]}

Bose, Anamika ^{[3
]}

Banerjee, Saptak ^{[1
]}

机构：

[1] Chittaranjan Natl Canc Inst, Dept Immunoregulat & Immunodiagnost, Kolkata, India

[2] Asutosh Coll, Dept Microbiol, Kolkata 700026, India

[3] Natl Inst Pharmaceut Educ & Res NIPER Sahibzada Aj, Dept Pharmaceut Technol Biotechnol, Mohali, Punjab, India

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

breast cancer (BC); breast cancer stem cells (BCSCs); tumor microenvironment (TME); innate immune cells; adaptive immune cells; DENDRITIC CELLS; MESENCHYMAL TRANSITION; SYSTEMIC THERAPY; TARGETED THERAPY; POOR-PROGNOSIS; T-CELLS; EXPRESSION; PROMOTE; METASTASIS; GROWTH;

D O I：

10.3389/fimmu.2023.1245421

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Breast cancer (BC) is globally one of the leading killers among women. Within a breast tumor, a minor population of transformed cells accountable for drug resistance, survival, and metastasis is known as breast cancer stem cells (BCSCs). Several experimental lines of evidence have indicated that BCSCs influence the functionality of immune cells. They evade immune surveillance by altering the characteristics of immune cells and modulate the tumor landscape to an immune-suppressive type. They are proficient in switching from a quiescent phase (slowly cycling) to an actively proliferating phenotype with a high degree of plasticity. This review confers the relevance and impact of crosstalk between immune cells and BCSCs as a fate determinant for BC prognosis. It also focuses on current strategies for targeting these aberrant BCSCs that could open avenues for the treatment of breast carcinoma.

引用

页数：18

共 129 条

[1] Natural Killer Cells: Development, Maturation, and Clinical Utilization
Abel, Alex M.
Yang, Chao
Thakar, Monica S.
Malarkannan, Subramaniam
[J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
[2] Evidence of lateral transmission of aggressive features between different types of breast cancer cells
Adriana Espinoza-Sanchez, Nancy
Vadillo, Eduardo
Carlos Balandran, Juan
Monroy-Garcia, Alberto
Pelayo, Rosana
Fuentes-Panana, Ezequiel M.
[J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 51 (05) : 1482 - 1496
[3] Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance
AlHossiny, Midrar
Luo, Linlin
Frazier, William R.
Steiner, Noriko
Gusev, Yuriy
Kallakury, Bhaskar
Glasgow, Eric
Creswell, Karen
Madhavan, Subha
Kumar, Rakesh
Upadhyay, Geeta
[J]. CANCER RESEARCH, 2016, 76 (11) : 3376 - 3386
[4] Dendritic cell maturation and cross-presentation: timing matters!
Alloatti, Andres
Kotsias, Fiorella
Gamelas Magalhaes, Joao
Amigorena, Sebastian
[J]. IMMUNOLOGICAL REVIEWS, 2016, 272 (01) : 97 - 108
[5] Aramini Beatrice, 2021, Oncotarget, V12, P230, DOI 10.18632/oncotarget.27870
[6] Arumugam P, 2016, INTEGR BIOL-UK, V8, P704, DOI [10.1039/c6ib00021e, 10.1039/C6IB00021E]
[7] Cancer stem cells as key drivers of tumour progression
Ayob, Ain Zubaidah
Ramasamy, Thamil Selvee
[J]. JOURNAL OF BIOMEDICAL SCIENCE, 2018, 25
[8] Recent Advances in Cancer Stem Cell-Targeted Immunotherapy
Badrinath, Narayanasamy
Yoo, So Young
[J]. CANCERS, 2019, 11 (03):
[9] C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes
Balamurugan, Kuppusamy
Mendoza-Villanueva, Daniel
Sharan, Shikha
Summers, Glenn H.
Dobrolecki, Lacey E.
Lewis, Michael T.
Sterneck, Esta
[J]. ONCOGENE, 2019, 38 (20) : 3765 - 3780
[10] The role of EMT and MET in cancer dissemination
Banyard, Jacqueline
Bielenberg, Diane R.
[J]. CONNECTIVE TISSUE RESEARCH, 2015, 56 (05) : 403 - 413

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