Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

被引：64

作者：

Luo, Hangqi ^{[1
]}

Gao, Shuai ^{[2
,3
]}

机构：

[1] Yale Sch Med, Yale Cardiovasc Res Ctr, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT 06511 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, Harvey Cushing Neurooncol Labs, Boston, MA 02115 USA

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2023年 / 362卷

关键词：

Photothermal therapy; Photodynamic therapy; Near-infrared-I; Near-infrared-II; Fluorescence imaging; Cancer therapy; MALIGNANT BRAIN-TUMORS; INDOCYANINE-GREEN; ORGANIC NANOPARTICLES; RATIONAL DESIGN; DENDRITIC CELLS; RECENT PROGRESS; T-CELLS; PHOTOSENSITIZERS; PORPHYRIN; DYE;

D O I：

10.1016/j.jconrel.2023.08.056

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phototherapy (including photothermal therapy, PTT; and photodynamic therapy, PDT) has been widely used for cancer treatment, but conventional PTT/PDT show limited therapeutic effects due to the lack of disease recognition ability. The integration of fluorescence imaging with PTT/PDT can reveal tumor locations in a realtime manner, holding great potential in early diagnosis and precision treatment of cancers. However, the traditional fluorescence imaging in the visible and near-infrared-I regions (VIS/NIR-I, 400-900 nm) might be interfered by the scattering and autofluorescence from tissues, leading to a low imaging resolution and high false positive rate. The deeper near-infrared-II (NIR-II, 1000-1700 nm) fluorescence imaging can address these interferences. Combining NIR-II fluorescence imaging with PTT/PDT can significantly improve the accuracy of tumor theranostics and minimize damages to normal tissues. This review summarized recent advances in tumor PTT/PDT and NIR-II fluorophores, especially discussed achievements, challenges and prospects around NIR-II fluorescence imaging-guided PTT/PDT for cancers.

引用

页码：425 / 445

页数：21

共 249 条

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