Synthesis and hypoglycemic activity of quinoxaline derivatives

被引：3
作者：
Jia, Weidong [1 ]
Wang, Jingjing [1 ]
Wei, Chengxi [1 ]
Bian, Ming [1 ]
Bao, Shuyin [1 ]
Yu, Lijun [1 ]
机构：
[1] Inner Mongolia Minzu Univ, Med Coll, Tongliao, Peoples R China
来源：
FRONTIERS IN CHEMISTRY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
diabetes; quinoxalinone derivatives; hypoglycemic activity; molecular docking; quinoxalinone; Pioglitazone;
D O I：
10.3389/fchem.2023.1197124
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, a new series of quinoxalinone derivatives (5a-5p, 6a-6n) was designed and its hypoglycemic activity was evaluated. The results showed that compounds 5i and 6b exhibited stronger hypoglycemic effects than the lead compounds and were comparable to the positive control Pioglitazone. 5i and 6b may exert hypoglycemic effects by alleviating cellular OS and modulating the interactions among GLUT4, SGLT2, and GLUT1 proteins. The alleviating cellular OS of compound 6b was better than that of 5i, and 6b was found to bind better than 5i for most of the screening targets. In summary, compound 6b is a potential lead compound with hypoglycaemic activity.3
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页数：14
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