STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats

被引：3
作者：
Ma, Lulin [1 ,3 ]
Deng, Daling [1 ,3 ]
Zhang, Tianhao [1 ,3 ]
Zhao, Wenjing [1 ,3 ]
Liu, Chengxi [2 ,3 ]
Huang, Shiqian [1 ,3 ]
Xu, Feng [1 ,3 ]
Wang, Yafeng [1 ,3 ]
Zhao, Shuai [3 ,4 ]
Ding, Yuanyuan [1 ,3 ]
Huang, Yan [3 ,5 ]
Wang, Kaixin [1 ,3 ]
Zhang, Yanyan [1 ,3 ]
Yang, Xinxin [1 ,3 ]
Cao, Song [3 ,4 ]
Chen, Xiangdong [1 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China
[2] Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang, Peoples R China
[3] Wuhan Univ, Zhongnan Hosp, Dept Anesthesiol, Wuhan 430071, Peoples R China
[4] Zunyi Med Univ, Dept Pain Med, Affiliated Hosp, Zunyi, Peoples R China
[5] First Peoples Hosp Jiangxia Dist, Dept Anesthesiol, Wuhan, Peoples R China
来源：
INFLAMMATION RESEARCH | 2023年 / 72卷 / 08期
关键词：
STING-IFN-I; Acute postoperative pain; Satellite glial cell; Macrophage; Neuroinflammation; MECHANICAL HYPERALGESIA; SPINAL-CORD; ANALGESIA; INFLAMMATION; MANAGEMENT; RECEPTOR; SURGERY; ALPHA; MODEL;
D O I：
10.1007/s00011-023-01764-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
BackgroundThe purpose of this study was to study the effect of STING-IFN-I pathway on incision induced postoperative pain in rats and its possible mechanisms.MethodsThe pain thresholds were evaluated by measuring the mechanical withdrawal threshold and the thermal withdrawal latency. The satellite glial cell and macrophage of DRG were analyzed. The expression of STING, IFN-a, P-P65, iNOS, TNF-& alpha;, IL-1 & beta; and IL-6 in DRG was evaluated.ResultsThe activation of STING-IFN-I pathway can reduce the mechanical hyperalgesia, thermal hyperalgesia, down-regulate the expression of P-P65, iNOS, TNF-& alpha;, IL-1 & beta; and IL-6, and inhibit the activation of satellite glial cell and macrophage in DRG.ConclusionsThe activation of STING-IFN-I pathway can alleviate incision induced acute postoperative pain by inhibiting the activation of satellite glial cell and macrophage, which reducing the corresponding neuroinflammation in DRG.
引用
收藏
页码：1551 / 1565
页数：15
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